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GlossarymRNA expression

process of producing mRNA from a gene's DNA template

mRNA expression, also known as messenger RNA expression, refers to the process by which the information encoded in a gene is used to produce mRNA molecules. These mRNA molecules serve as templates for synthesizing proteins, which perform various functions in the body. Measuring mRNA expression levels can provide insights into how active a particular gene is under certain conditions, which is crucial for understanding biological processes and disease mechanisms, including those related to hair growth and alopecia.

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research Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene

1 citations , February 2025 in “Journal of Dairy Science”

The SLICK1 allele in Holstein heifers affects hair and immune traits without altering prolactin signaling.

research Molecular characterization, expression and methylation status analysis of BMP4 gene in skin tissue of Liaoning cashmere goat during hair follicle cycle

18 citations , July 2016 in “Genetica”

BMP4 gene is crucial for hair follicle development in Liaoning cashmere goats.

research Expression and Analysis of TBX3 Gene in the Skin from Three Locations on Dun Mongolian Bider Horse

December 2024 in “Genes”

TBX3 gene affects horse coat color, with higher expression in darker areas.

research The Association of Gene Expression and Single Nucleotide Polymorphism (rs 6152 SNP) in Androgen Receptor Gene with Recurrent Spontaneous Abortion (RSA) in Iraqi Women

March 2021 in “Medico-Legal Update”

The androgen receptor gene doesn't affect women with recurrent spontaneous abortions, but having a mutant genotype might protect against it.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research De NovoTranscriptome Assembly and Differential Gene Expression Profiling of ThreeCapra hircusSkin Types during Anagen of the Hair Growth Cycle

12 citations , January 2013 in “International Journal of Genomics”

The study identified key genes involved in goat hair growth.

research Expression of the RORα gene in Inner Mongolian cashmere goat hair follicles

7 citations , January 2015 in “Genetics and molecular research”

The RORα gene is active in different parts of cashmere goat hair follicles and may be influenced by melatonin, especially in December when hair growth changes.

research Gene Expression of Osteopontin in Alopecia Areata? A Case-Controlled Study

1 citations , October 2014 in “Skin Pharmacology and Physiology”

People with alopecia areata have higher levels of osteopontin, which might be important in the disease's development, but this doesn't relate to how severe the disease is.

research Thehairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype

52 citations , October 1999 in “Developmental Dynamics”

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol), Adenosine, and Minoxidil in Human Dermal Papilla Cells

research Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells

2 citations , June 2017 in “Journal of biomedicine and translational research”

Lychee fruit polyphenol (Oligonol®) may regulate genes linked to cell growth and inflammation in human scalp cells.

research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle.

26 citations , December 1990 in “Journal of Biological Chemistry”

Two specific genes are more active during hair growth in mice.

research Analysis of LncRNA and mRNA Expression Profiles in Skin Tissues of Super Merino Sheep and Small-Tailed Han Sheep

November 2023

Researchers found genes in sheep that may affect hair growth and wool quality.

research Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment

7 citations , December 2019 in “Experimental and Therapeutic Medicine”

WNT10B affects hair growth by altering gene activity in hair cells.

research Molecular cloning, characterization, and expression of sheep FGF5 gene

11 citations , October 2014 in “Gene”

Researchers identified a new variant of the FGF5 gene in sheep that affects hair length.

Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid

research Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

2 citations , November 2017 in “PloS one”

Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

research Molecular Genetic Characteristics of the Hoxc13 Gene and Association Analysis of Wool Traits

January 2024 in “International journal of molecular sciences”

Hoxc13 gene affects wool length in Gansu alpine fine-wool sheep.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

research Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice

July 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair loss in certain mice is linked to changes in keratin-related genes.

research Polymorphic CAG Repeat Numbers in the Androgen Receptor Gene of Female Pattern Hair Loss in a Han Chinese Population

5 citations , January 2016 in “Dermatology”

No significant link between CAG repeat numbers and female pattern hair loss in Han Chinese population.

research Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development

5 citations , October 2022 in “BMC genomics”

Certain microRNAs are important for sheep hair follicle development and could help improve wool quality.

research Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.

24 citations , July 1994 in “Molecular Endocrinology”

Researchers found an RNA transcript that might help control a growth factor linked to tumor development.

research Expression patterns of TRα and CRABPII genes in Chinese cashmere goat skin during prenatal development

August 2015 in “Han'gug dongmul jawon gwahag hoeji/Han-guk dongmul jawon gwahak hoeji/Journal of animal science and technology”

TRα and CRABPII genes change their activity levels during goat fetal skin development.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

24 citations , January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

research Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

10 citations , March 2022 in “Communications biology”

A new non-invasive method can analyze skin mRNA to understand skin diseases better.

research Expression of SPARC (secreted protein acidic rich in cysteine) throughout the hair cycle in rats

1 citations , January 2004 in “Adelaide Research & Scholarship (AR&S) (University of Adelaide)”

SPARC likely aids in tissue remodeling during the hair cycle, not in starting new hair growth phases.

research Spatiotemporal Expression Characterization of KRTAP6 Family Genes and Its Effect on Wool Traits

January 2024 in “Genes”

KRTAP6 genes affect wool quality in sheep.

MRNA Levels of Aromatase, 5α-Reductase Isozymes, and Prostate Cancer-Related Genes in Plucked Hair from Young Men with Androgenic Alopecia

research mRNA Levels of Aromatase, 5α-Reductase Isozymes, and Prostate Cancer-Related Genes in Plucked Hair from Young Men with Androgenic Alopecia

December 2023 in “International Journal of Molecular Sciences”

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

research Expression of Hex during feather bud development

16 citations , January 2005 in “The International Journal of Developmental Biology”

Hex gene plays a crucial role in starting feather development in chick embryos.

research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.