57 citations
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February 1975 in “Journal of Clinical Investigation” Minoxidil boosts plasma renin activity, influenced by control plasma renin activity and changes in sympathetic tone.
July 2017 in “Nursing2023” Actemra is approved for a specific artery condition, HIV treatment adherence has improved, women may pay more for a hair loss product, and incorrect dosing of blood thinners can be risky.
January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology” Minoxidil increases cell layer permeability by reducing tight junction proteins and raising ROS levels.
Cialis and Finasteride could be repurposed to treat aggressive melanoma.
143 citations
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May 2002 in “PubMed” LGD1069 effectively prevents breast tumors in mice without toxicity.
4 citations
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December 2024 in “European Journal of Medicinal Chemistry” New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.
47 citations
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November 1982 in “Journal of Cardiovascular Pharmacology” Nitrendipine and nifedipine effectively block muscle contractions, while papaverine relaxes them and minoxidil needs high amounts to work.
33 citations
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May 2017 in “Journal of Clinical Oncology” ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.
January 2018 in “日本薬理学会年会要旨集 =” Minoxidil may protect the brain from damage by preventing cell death and energy loss.
19 citations
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May 1979 in “Archives of internal medicine” Minoxidil effectively lowers blood pressure and initially increases plasma renin activity without raising aldosterone levels.
16 citations
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December 2012 in “Bioinformation” Curcumin, EGCG, barringtozenol, and finasteride are effective VEGFR inhibitors.
119 citations
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June 2005 in “Journal of Molecular and Cellular Cardiology” Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.
1 citations
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March 2009 in “The Journal of Urology” Combination therapy with fesoterodine and doxazosin improves bladder function and delays BPH progression.
505 citations
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October 2011 in “Journal of clinical oncology” MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
May 2024 in “News Digital Object Group” December 2025 in “International Journal of Dermatology” Combining low-dose oral minoxidil with immunomodulators shows promise for treating alopecia areata but needs more research.
23 citations
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March 1988 in “Biochemical Pharmacology” Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.
April 2023 in “Medicina Clínica (english Edition)” 4 citations
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January 2009 in “International journal of trichology” Minoxidil topical foam is a better, less irritating treatment for hair loss.
April 2017 in “Journal of Investigative Dermatology” Sirolimus and propranolol may reduce abnormal cell growth and improve lymphatic malformations in children.
10 citations
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March 2022 in “Healthcare” Mineralocorticoid receptor antagonist therapy does not significantly reduce mortality in COVID-19 patients.
9 citations
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November 2018 in “Acta Clinica Belgica” Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.
September 2002 in “Oncology Times” Promising cancer treatments were found, but the manufacturer closed.
102 citations
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September 1977 in “The Lancet” Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.
August 2013 in “Fertility and sterility” Metformin can help diagnose and treat high testosterone levels in women, often due to insulin resistance rather than a tumor.
Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.
April 2025 in “Frontiers in Pharmacology” Canagliflozin helps overcome progestin resistance in certain endometrial cancer cells.
February 2026 in “Toxicology Letters” MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.
15 citations
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October 2003 in “Annals of Oncology” Hair loss can occur as a side effect of certain breast cancer treatments, but minoxidil can help regrow hair.
September 2025 in “Arthritis Research & Therapy” BMS-470539 reduces skin fibrosis and inflammation.