277 citations
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July 2011 in “Journal of the Dermatology Nurses’ Association” The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.
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December 2020 The skin is the body's largest organ, with layers, cells, and structures that protect and support it.
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September 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” Basal stem cells in the skin have distinct types that are crucial for skin structure and health.
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November 2014 The skin protects the body, regulates temperature, senses touch, and makes vitamin D.
27 citations
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August 2016 Understanding skin structure and function is key to managing skin diseases and improving quality of life.
85 citations
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July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
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January 1990 in “Skin Pharmacology and Physiology” The method and source of keratinocytes affect the structure of reconstructed skin.
February 2019 in “American International Journal of Humanities Arts and Social Sciences” The dermis of Millivora Capenesis has two layers with various connective tissues, blood vessels, glands, and sensory structures.
65 citations
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December 2000 in “PubMed” The biology of skin and hair is complex and not fully understood.
January 2017 in “대한미용학회지” The cuticle layer in hair follicles thickens during keratinization due to incomplete cytosol loss.
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May 2024 in “Tissue Barriers” The skin's outer layer relies on lipids and proteins to protect against damage.
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January 2022 The skin is essential for protection, temperature control, and immune defense.
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January 2006 in “International review of cytology” Vertebrate skin evolved to be more specialized and complex, especially in land animals.
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January 2008 in “Yearbook of Dermatology and Dermatologic Surgery” One type of progenitor cell can maintain normal skin in mice.
June 2014 in “Experimental dermatology” The epidermis is crucial for hair growth.
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July 1994 in “Journal of Dermatological Science” Hair follicle cells need complex interactions to fully differentiate.
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December 2024 in “Tissue Barriers” The epidermis is the stiffest skin layer.
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January 1981 in “Cells Tissues Organs” Human hair cuticle has five cell layers with specific junctions and granules.
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September 2005 in “Experimental dermatology” The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.
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January 2014 in “Elsevier eBooks” The skin is a complex barrier that protects the body, regulates temperature, and helps with immune responses.
November 2022 in “Journal of Investigative Dermatology” Human-induced stem cell-created skin models can help understand skin diseases by studying the skin's layers.
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March 1986 in “British Veterinary Journal” Canine skin has two main layers: the epidermis and dermis, with a supportive subcutis layer.
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May 2022 in “Stem cell reports” The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.
130 citations
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February 2005 in “Proceedings of the National Academy of Sciences” Corneal cells can transform into skin and hair cells through specific signals.
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January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
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January 1977 in “Archives of dermatological research” Mouse tail skin has different keratinization near hair follicles and scales.
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September 2016 in “PLoS ONE” Cell division orientation varies by body site and is linked to epidermal thickness and cell density.
PmtHEE is a better model for studying pigmented skin because it includes melanocytes and shows improved cell differentiation.
53 citations
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September 1999 in “Journal of Synchrotron Radiation” Keratinous tissues have multiple structural layers, including ordered keratin and lipid granules.