1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
333 citations
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February 2010 in “Cell Stem Cell” Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.
320 citations
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December 2018 in “Frontiers in Immunology” Changing how mesenchymal stromal cells are grown can improve their healing abilities.
236 citations
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
179 citations
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July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
160 citations
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January 2017 in “Development” Blood vessels and specific genes help turn cartilage into bone when bones heal.
144 citations
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September 2012 in “Genes & development” Aging causes skin stem cells to work less effectively.
136 citations
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May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
135 citations
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December 2015 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
107 citations
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August 2012 in “Seminars in Cell & Developmental Biology” The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
97 citations
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September 2016 in “Reviews in Endocrine and Metabolic Disorders” The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
94 citations
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June 2016 in “The FASEB Journal” The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.
77 citations
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July 2020 in “Cell” Muscles and nerves that cause goosebumps also help control hair growth.
76 citations
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February 2021 in “International Journal of Molecular Sciences” Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.
61 citations
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January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology” Beta-catenin is crucial for skin cell growth, development, and cancer formation.
60 citations
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July 2011 in “Stem Cells and Development” Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
56 citations
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May 2017 in “Nature Cell Biology” Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
51 citations
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November 2013 in “Drug Discovery Today” Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.
47 citations
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July 2013 in “Pharmacological Reviews” Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
44 citations
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September 2019 in “The EMBO Journal” Lymphatic vessels are essential for hair follicle growth and skin regeneration.
42 citations
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February 2021 in “Signal Transduction and Targeted Therapy” Hair follicle regeneration possible, more research needed.
40 citations
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December 2015 in “Stem Cells International” Mesenchymal stem cells help improve wound healing by reducing inflammation and promoting skin cell growth and movement.
39 citations
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January 2016 in “PubMed” Understanding how EDC genes are regulated can help develop better drugs for skin diseases.
38 citations
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June 2019 in “International Journal of Molecular Sciences” Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.
37 citations
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March 2006 in “Regulatory Peptides” Mice skin has components that could help with hair growth and might be used for diabetes treatment.
36 citations
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August 2011 in “Journal of Controlled Release” Genetically-altered adult stem cells can help in wound healing and are becoming crucial in regenerative medicine and drug design.
36 citations
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March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
28 citations
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October 2019 in “Seminars in Cell & Developmental Biology” Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.
28 citations
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March 2010 in “Histochemistry and Cell Biology” Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.
25 citations
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March 2017 in “Experimental Dermatology” The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.