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GlossaryN-cadherin

protein aiding cell adhesion, crucial for tissue development

N-cadherin, also known as Neural cadherin or CDH2, is a protein that helps cells stick together, playing a crucial role in the development and maintenance of tissues, especially in the nervous system. It is important for processes like cell signaling, tissue formation, and wound healing, and its dysfunction can be linked to various diseases, including cancer and neurodegenerative disorders.

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research 269 The PPAR-γ modulator, N-acetyl-GED, protects from epithelial-mesenchymal-transition to human hair follicles: Potential relevance for scarring alopecia

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

N-acetyl-GED may help prevent and partially reverse a process that leads to scarring hair loss.

research DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

DHT deficiency can disrupt cell connections in rat testes, possibly affecting fertility.

research Following fibroblast lineages in dermal development and scars

January 2021 in “Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)”

N-Cadherin is crucial in scar formation, offering potential for scar prevention therapies.

research 1380 PPAR-γ modulation as a novel therapeutic strategy for scarring alopecia

April 2018 in “Journal of Investigative Dermatology”

A new treatment using AGED to modulate PPAR-γ shows promise for treating scarring hair loss by protecting and repairing hair follicle cells.

research The variable cell

October 2005 in “Nature reviews. Molecular cell biology (Print)”

Hairless protein is key for hair growth, cell differences cause gene expression variation, and the N-end rule pathway senses nitric oxide for protein breakdown.

research Novel compound heterozygous cadherin 3 mutations in hypotrichosis and juvenile macular dystrophy

1 citations , June 2022 in “Chinese medical journal/Chinese Medical Journal”

Two new mutations in the CDH3 gene cause hair loss and vision problems in a young girl.

research Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells

8 citations , June 2001 in “Journal of Biological Chemistry”

A truncated protein linked to breast cancer may change cell adhesion.

research Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle

45 citations , April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.

The Role of P-Cadherin in Skin Biology and Pathology: Lessons from the Hair Follicle

research The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle

15 citations , February 2015 in “Cell & tissue research/Cell and tissue research”

P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

27 citations , July 2017 in “Scientific Reports”

N-WASP is essential for healthy skin and preventing inflammation.

research Testosterone Down-regulates Expression of αVβ3-integrin, E-cadherin and Mucin-1 during Uterine Receptivity Period in Rats

5 citations , October 2018 in “Sains Malaysiana”

Testosterone reduces key molecules needed for early pregnancy in rats.

research Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications

4 citations , December 2013 in “Acupuncture and related therapies”

N-acetyl-cysteine shows promise in treating various diseases and may improve skin and hair conditions, but more research is needed on dosages and long-term effects.

research Alk1 acts in non-endothelial VE-cadherin+ perineurial cells to maintain nerve branching during hair homeostasis

September 2023 in “Nature communications”

Alk1 in specific cells is crucial for proper nerve branching and hair function.

research Dual blockage of P-cadherin and c-Met synergistically inhibits the growth of head and neck cancer

May 2025 in “Cellular Oncology”

Blocking both P-cadherin and c-Met can effectively stop head and neck cancer growth.

research 144 Deciphering the role of the hexosamine pathway in skin homeostasis

August 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The hexosamine pathway helps protect skin cells from stress and may improve skin and hair health.

research 194 An underlying mechanism of hair loss in acrodermatitis enteropathica

August 2016 in “Journal of Investigative Dermatology”

Zinc deficiency disrupts hair growth and cycle, but zinc supplements can fix this.

research 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision

April 2017 in “Journal of Investigative Dermatology”

Sweat glands and hair follicles are determined by opposing signals, with BMPs promoting sweat glands and blocking BMPs leading to hair follicles.

research 197 A novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair

August 2016 in “Journal of Investigative Dermatology”

Researchers found a new genetic mutation linked to a hair condition in a Japanese boy.

research Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

29 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.

research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization

28 citations , March 2017 in “Endocrinology”

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

research Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/− Mice

8 citations , March 2014 in “American Journal of Pathology”

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

research The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice

January 2026 in “PLoS Biology”

ARHGEF3 is essential for proper hair follicle development in mice.

research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair

research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair

46 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.