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Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Folliculin: A surprising molecular brake in the human hair follicle

March 2026 in “Journal of Investigative Dermatology”

Folliculin slows hair growth, and blocking it might help treat hair loss.

Finasteride, Isotretinoin, and Serotonin Reuptake Inhibitors: A Study on Enduring Sexual Dysfunction

research Finasteride/isotretinoin/serotonin uptake inhibitors

December 2018 in “Reactions Weekly”

Some medications may cause lasting sexual dysfunction.

research Efficacy of an oral contraceptive containing EE 0.03 mg and CMA 2 mg (Belara®) in moderate acne resolution: a randomized, double-blind, placebo-controlled Phase III trial

42 citations , May 2009 in “Contraception”

The oral contraceptive with ethinyl estradiol and chlormadinone acetate is effective in treating moderate acne.

research Dihydrotestosterone and Finasteride Effects on Alcohol Cue‐Elicited Brain Activity in Males With Heavy Episodic Drinking

January 2026 in “Addiction Biology”

Finasteride may help reduce alcohol cravings and related brain activity.

Novel Systematics of Nomenclature and Classification of Female Functional Androgenization (Including Polycystic Ovary Syndrome and Non-Classic Congenital Adrenal Hyperplasia)

research Novel Systematics of Nomenclature and Classification of Female Functional Androgenization (Including Polycystic Ovary Syndrome and Non-Classic Congenital Adrenal Hyperplasia)

8 citations , February 2010 in “Journal für Kardiologie (Krause & Pachernegg GmbH)”

A new system helps better diagnose and treat female androgenization conditions like PCOS.

Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition

research Comparison of finasteride (proscar®), a 5α reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5α reductase inhibition

124 citations , January 1993 in “The Prostate”

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques

research Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques

18 citations , January 1998 in “Endocrine”

RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.

Dysregulation of Leukemia Inhibitory Factor (LIF) Signaling Pathway by Supraphysiological Dose of Testosterone in Female Sprague Dawley Rats During Development of Endometrial Receptivity

research Dysregulation of Leukaemia Inhibitory Factor (LIF) Signalling Pathway by Supraphysiological Dose of Testosterone in Female Sprague Dawley Rats During Development of Endometrial Receptivity

January 2025 in “Biomedicines”

High testosterone levels can harm fertility by disrupting the LIF signaling pathway in the uterus.

Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Androgenetic Alopecia: A Split Study

research Therapeutic-effects-of-growth-factor-cocktail-including-fibroblast-growth-factor-9-in-patients-with-androgenetic-alopecia-a-split-study

January 2016 in “Global dermatology”

A treatment called Cellcurin, combined with microneedling, significantly increased hair density and diameter in patients with hair loss.

research Additive in vivo growth-inhibitory effects of flutamide and finasteride on androgen-sensitive Shionogi 115 carcinoma

6 citations , January 1996 in “Endocrine-related Cancer”

Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.

research Contraceptive Implants

14 citations , April 2005 in “African Journal of Reproductive Health”

Contraceptive implants are effective, long-lasting, and safe with manageable side effects.

research 185 Infrared and high frequency ultrasound imaging of skin lesions in atopic dermatitis and psoriasis vulgaris

September 2019 in “Journal of Investigative Dermatology”

Sandalore®, a synthetic scent, reduced hair loss and improved hair growth in women with telogen effluvium.

Neonatal Allopregnanolone or Finasteride Administration Modifies Hippocampal K+ Cl− Co-Transporter Expression During Early Development in Male Rats

research Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats

10 citations , May 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Allopregnanolone increases KCC2 expression in baby male rats' brains, while finasteride doesn't affect it.

research Novos sistemas de veiculação da finasterida e sua aplicação no tratamento da alopécia

January 2016 in “Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)”

Topical finasteride formulations can treat hair loss effectively with fewer side effects.

The Administration of Flumethasone by Three Different Routes, Its Measurement in the Plasma, and Some Effects on Wool Growth in Merino Wethers

research The Administration of Flumethasone, by Three Different Routes, its Measurement in the Plasma and Some Effects on Wool Growth in Merino Wethers

9 citations , December 1978 in “Australian Journal of Biological Sciences”

Flumethasone causes wool shedding in Merino wethers, with recovery in about 60 days.

research Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study

69 citations , July 2015 in “Pharmacotherapy”

Low-dose finasteride may cause lasting sexual dysfunction and suicidal thoughts in young men.

research 폐경기 이후 여성의 남성형 탈모증(대머리) 환자에서의 Finasteride 사용경험

September 2006

Finasteride may help treat hair loss in postmenopausal women.

Enhancing Hair Follicle Stimulation: A Nanoliposome-Based Delivery of Lavender Essential Oil (Lavandula Angustifolia Mill.)

research Enhancing Hair Follicle Stimulation: A Nanoliposome-Based Delivery of Lavender Essential Oil (<i>Lavandula angustifolia</i> Mill.)

August 2025 in “Tropical Journal of Natural Product Research”

LEON gel significantly boosts hair growth without irritation.

research Frontal Fibrosing Alopecia: An Update on Epidemiology and Treatment

7 citations , October 2015 in “Actas Dermo-Sifiliográficas”

New treatments for Frontal Fibrosing Alopecia show promise, especially finasteride and dutasteride, with most patients seeing improvement or stabilization.

research Epidermal growth factor receptor inhibitors and hair

4 citations , March 2008 in “Journal of the American Academy of Dermatology”

research Galenic-Pharmaceutical Study of Pieces of Proscar (Finasteride 5mg) and Finasteride 1mg Capsules versus Propecia® in the Treatment of Androgenetic Alopecia

July 2000 in “Hair transplant forum international”

research SAT-130 Estrogen deficiency in patients with reduced fat mass as a cause of non-alcoholic fatty liver disease

October 2025 in “Journal of the Endocrine Society”

Low estrogen due to poor nutrition can lead to non-alcoholic fatty liver disease.

research Does eflornithine help women face hirsutism?

August 2007 in “Drug and therapeutics bulletin”

Eflornithine's effectiveness for women with facial hirsutism is unclear.

research Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration

July 2025 in “International Journal of Biological Macromolecules”

The microneedle patch boosts hair growth by reducing DHT and oxidative stress.

research Finasteride, a Type 2 5α-reductase inhibitor, in the treatment of men with androgenetic alopecia

32 citations , April 1999 in “Expert Opinion on Investigational Drugs”

Finasteride effectively treats male hair loss, improving growth and density.

Signal Detection Between 5-Alpha Reductase Inhibitors and the Risk of Suicidality and Depression: An International Pharmacovigilance Analysis

research Signal detection between 5-alpha reductase inhibitors and the risk of suicidality and depression: an international pharmacovigilance analysis

1 citations , June 2025 in “European Journal of Clinical Pharmacology”

Finasteride may increase the risk of suicidality and depression, especially in younger people.

Revitalizing Hair Growth: A New Regimen Utilizing Growth Factor Concentrate for Hair Loss Treatment

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