April 2016 in “Journal of Investigative Dermatology” Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.
16 citations
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September 2015 in “International Journal of Molecular Sciences” A specific gene variant causes severe skin issues and increases infection risk, requiring careful medical monitoring.
7 citations
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December 2008 in “Journal of Dermatological Science” Progranulin overexpression leads to shorter, thinner hair and increased cell death in mouse hair follicles.
72 citations
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November 2012 in “PloS one” The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.
The gene Endothelin 3 makes mice's fur darker by increasing pigment cells and pigment levels.
37 citations
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January 2009 in “The Journal of Dermatology” Hair follicle stem cells can turn into various cell types and help repair nerves.
May 2022 in “Frontiers in Cell and Developmental Biology” miR-29a-5p prevents the formation of early hair structures by targeting a gene important for hair growth and is regulated by a complex network involving lncRNA627.1.
132 citations
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August 2008 in “Development” Dlx3 is essential for hair growth and regeneration.
226 citations
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August 2006 in “Molecular and Cellular Biology” EGF signaling affects gene expression in skin cells, influencing hair growth and potentially cancer.
January 2007 in “The FASEB journal” Human hair keratins help nerve regeneration and support Schwann cell activity.
July 2025 in “Journal of Investigative Dermatology” Nelfb is essential for dermal fat development and survival.
January 2026 in “Therapeutics” SCUBE3 is a potential target for cancer and alopecia treatment but is challenging to target due to its varied roles.
29 citations
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July 2014 in “PloS one” Meis1 is crucial for skin health and tumor development.
150 citations
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June 1999 in “Oncogene” GPC1 is important for blood vessel growth in hair follicles and could help treat hair loss.
6 citations
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December 2019 in “Frontiers in genetics” GLI1 might protect against the start of skin cancer and is not linked to cancer severity.
72 citations
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July 2002 in “Journal of Investigative Dermatology” Desmoglein 1 can partly make up for the loss of Desmoglein 3 in hair adhesion but not in mucous membranes.
25 citations
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November 2018 in “Cell reports” The study concluded that specific proteins are necessary to maintain the structure that holds epithelial cells tightly together.
10 citations
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February 2013 in “PLoS ONE” Neprilysin is important for hair growth regulation.
1 citations
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December 2016 in “Revista română de medicină de laborator” The NIPAL4 mutation c.527C>A is common in Romanian patients with autosomal recessive congenital ichthyosis.
GPC1 is important for blood vessel growth in hair follicles and could help treat hair loss.
19 citations
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August 2013 in “Journal of Molecular Neuroscience” 2 citations
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September 2020 in “International Journal of Molecular Sciences” Removing certain hair follicle stem cells worsens skin reactions to allergens.
396 citations
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May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
1 citations
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April 1998 in “PubMed” Nexin 1 helps control hair growth in young rats.
1 citations
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January 2025 in “Burns & Trauma” Targeting Midkine can help reduce pain and itching in keloids.
82 citations
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May 2009 in “Development” EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.
117 citations
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August 1999 in “Nature Genetics”
August 2019 in “Stem cells” New treatments for hair loss, fertility, and wound healing are being explored.
13 citations
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February 2025 in “Nature Communications” A new neural network helps identify key regulators in cell changes, aiding in understanding diseases and finding new treatments.