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Stopping alcohol after long-term use causes anxiety and changes brain chemicals.

Changing neuroactive steroid levels early in life can affect how adult rats respond to alcohol's stimulating effects.

Gut microbes significantly affect brain steroid levels.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

Pregnancy increases certain GABA_A receptors in rat brains, influenced by steroid levels.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Neurosteroids help protect fetal brains from asphyxia damage.

A new method accurately measures nine neuroactive steroids in small blood samples, helping to study brain diseases.

Early NAS level changes affect alcohol consumption vulnerability.

The steroids allopregnanolone and allotetrahydrodeoxycorticosteron worsened absence seizures in rats.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

Metabolites and diet affect hair growth cycles in cashmere goats.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

GABAergic steroid precursors reduce ethanol withdrawal symptoms in certain mice.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Skin diseases like acne and psoriasis are linked to stress, gut health, and inflammation, with new treatments focusing on gut and mind-body approaches.

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

Androgen use may increase the risk of stroke, but more research is needed.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.

Inhibiting 5α-reductase during late pregnancy shortens gestation, reduces litter size, and harms memory in rat offspring.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

Ovarian and stress hormones can change GABA A receptors through neurosteroids.

Finasteride blocks progesterone's effect on absence seizures in rats.