research Editorial: Targeted immunological therapies in dermatology
Targeted immunological therapies offer safer and more effective treatments for skin conditions like eczema and psoriasis.
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research Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells
Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.
research Depressive Disorder and Dermatological Autoimmune Diseases
Depression and skin autoimmune diseases are linked, needing combined care for better treatment.
research IL-15 in T-Cell Responses and Immunopathogenesis
IL-15 is key for T cell function and could help improve treatments for immune-related diseases.
research Regulatory T cells in dominant immunologic tolerance
Regulatory T cells help prevent autoimmunity and have potential for treating autoimmune diseases.
research Clinical Snippets
Increased pigmentation may protect skin from UVB, new targets for skin disease treatments were identified, sunscreen ingredients don't affect hormones, TNF-α inhibitors may help diabetic wounds, and certain treatments could prevent chemotherapy-induced hair loss.
research Could Vaccination against COVID-19 Trigger Immune-Mediated Inflammatory Diseases?
COVID-19 mRNA vaccines may increase the risk of flare-ups in certain inflammatory diseases.
research Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.
Neurotrophins regulate nerve growth by balancing promotion and suppression.
research Rethinking regeneration: empowerment of stem cells by inflammation
Inflammation helps stem cells repair tissue by directing their behavior.
research The Important Role of Leptin in Modulating the Risk of Dermatological Diseases
Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.
research T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus
Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.
research Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game?
Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.
research The regenerative potential of skin and the immune system
The skin's immune system helps it regenerate and fight infections.
research Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling?
Blocking EGFR can cause skin inflammation by disrupting IL-1 signaling.
research MicroRNA-Enriched Exosomes from Different Sources of Mesenchymal Stem Cells Can Differentially Modulate Functions of Immune Cells and Neurogenesis
Exosomes from different stem cell sources affect immune cells and brain cell growth differently.
research The skin as an endocrine organ
The skin produces and processes hormones, affecting both local and overall body functions.
research EMATOPOIESIS REVOLVES AROUND THE PRIMORDIALEVOLUTIONAL RHYTHM OF INNATE IMMUNITY AND PURINERGIC SIGNALING – A JOURNEY TO THE DEVELOPMENTAL ROOTS
Ancient immune and signaling pathways still regulate blood cell development.
research sc-eQTL unveil Immunogenetic Architecture of Polycystic Ovary Syndrome
PCOS involves genetic and immune factors, especially T cells, affecting its development.
research Regulatory T cell dysfunction and immunotherapeutic breakthroughs in type 1 diabetes
Next-generation Treg therapies could help achieve lasting immune tolerance in type 1 diabetes.
research Treg–tissue cell interactions in repair and regeneration
Treg cells help repair and regenerate tissues by interacting with local cells.
research Immune niches for hair follicle development and homeostasis
Immune cells are crucial for hair growth and preventing hair loss.
research Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain
Androgens can affect glucocorticoid signaling in specific mouse brain areas.
research Common Skin Diseases and Metabolic Syndrome: A Proinflammatory Chemokine Perspective
Chronic skin diseases and metabolic syndrome are linked by shared inflammation pathways.
research Nucleus‐specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus
Brain-made chemicals can control nerve cell function differently in various parts of a mouse's brain, which may help us understand neurological conditions.
research Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance
Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.
research The Anagen Hair Cycle Induces Systemic Immunosuppression of Contact Hypersensitivity in Mice
Hair growth phase in mice weakens certain immune responses.
research 067 BELCOMID: BELgian Cohort study of COVID-19 in Immune Mediated Inflammatory Diseases
COVID-19 infection rates were low in patients with immune diseases, regardless of their treatment type.
research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice
TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.
research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice
TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.
research Aberrant inflammasome activation as a driving force of human autoimmune skin disease
Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.