306 citations
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April 2019 in “International Journal of Molecular Sciences” The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.
280 citations
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July 2018 in “Antioxidants” Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.
252 citations
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April 2009 in “Seminars in Cell & Developmental Biology” The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
147 citations
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November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
131 citations
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August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
127 citations
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January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
125 citations
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August 2020 in “Frontiers in Immunology” Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.
119 citations
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July 2016 in “Annals of the New York Academy of Sciences” Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.
119 citations
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January 2012 in “Nutrition & Metabolism” Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.
98 citations
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November 2014 in “PLoS ONE” Hyaluronidase speeds up wound healing and reduces inflammation.
88 citations
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January 2019 in “Journal of Tissue Engineering and Regenerative Medicine” Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.
66 citations
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March 2009 in “British journal of surgery” Hidradenitis suppurativa treatment should be tailored to the individual, with quitting smoking being important.
65 citations
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February 2017 in “Pflügers Archiv - European Journal of Physiology” Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.
55 citations
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April 2010 in “Cancer and Metastasis Reviews” TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
51 citations
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March 2019 in “Journal of cellular physiology” Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.
51 citations
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October 2002 in “British Journal of Dermatology” Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.
49 citations
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November 1992 in “Archives of dermatology” Different treatments for alopecia areata have varying success rates and side effects; intralesional steroids are most effective.
47 citations
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September 2023 in “Pharmacological Reports” Vitamins A, B3, C, D, and E can improve skin health and immunity.
46 citations
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May 2020 in “Cureus” Zinc is vital for immune health, growth, and preventing diarrhea.
42 citations
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April 2021 in “Journal of clinical pharmacology” Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.
40 citations
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January 2010 in “Indian Journal of Dermatology, Venereology and Leprology” Certain diets can affect skin conditions, but more research is needed to understand these relationships fully.
32 citations
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March 2014 in “PLOS ONE” Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.
30 citations
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February 2022 in “Stem Cell Reviews and Reports” Stem cell treatments may improve burn wound healing.
29 citations
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September 2020 in “International Journal of Molecular Sciences” The document concludes that freeze-dried platelet-rich plasma shows promise for medical use but requires standardization and further research.
29 citations
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May 2020 in “npj Regenerative Medicine” Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.
27 citations
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November 2021 in “Scientific Reports” Men are more affected by COVID-19 due to differences in immune responses and protein expression.
27 citations
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December 2015 in “Mayo Clinic Proceedings” The document concludes that lifestyle changes and medical treatments can significantly reduce symptoms of Hidradenitis Suppurativa, a chronic skin condition.
25 citations
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December 2018 in “Human Molecular Genetics” The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.
24 citations
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October 2017 in “Biomolecules” Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.
23 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” Using defensins to activate stem cells may improve skin aging signs without causing inflammation.