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GlossaryNicotinamide Adenine Dinucleotide Phosphate Hydrogen

coenzyme NADPH provides electrons for cellular reactions

Nicotinamide Adenine Dinucleotide Phosphate Hydrogen, commonly abbreviated as NADPH, is a coenzyme that plays a crucial role in cellular processes. It acts as a reducing agent, donating electrons and hydrogen to various biochemical reactions, which is essential for processes like fatty acid synthesis and the detoxification of reactive oxygen species.

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Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

research Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

81 citations , July 2008 in “The Journal of Clinical Endocrinology and Metabolism”

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

research Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Beta-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

research β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

February 2024 in “Molecules/Molecules online/Molecules annual”

NMN could potentially treat hair loss by reducing oxidative stress and improving cell health.

research Phenyl Propanoid 1’s-1′-Acetoxychavicol Acetate Protects Against Testosterone-Induced Alopecia by Inhibiting Nadph Oxidase

April 2025

ACA from Alpinia galanga may prevent testosterone-related hair loss.

Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks for Diabetic Wound Healing

research Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing

4 citations , December 2023 in “Advanced science”

New injectable hydrogels with gelatin, metal, and tea polyphenols help heal diabetic wounds faster by controlling infection, improving blood vessel growth, and managing oxidative stress.

research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

277 citations , February 2013 in “Science Signaling”

Mitochondrial reactive oxygen species are essential for skin and hair development.

In Vitro–In Vivo Assessments of Apocynin-Hybrid Nanoparticle-Based Gel as an Effective Nanophytomedicine for Treatment of Rheumatoid Arthritis

research In vitro–in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis

11 citations , June 2023 in “Drug Delivery and Translational Research”

The gel with apocynin-loaded nanoparticles shows promise for treating rheumatoid arthritis.

research Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress

43 citations , August 2016 in “International Journal of Nanomedicine”

Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

72 citations , January 2011 in “Current Pharmaceutical Design”

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

30 citations , October 2020 in “Nature Communications”

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

research Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors

13 citations , January 2017 in “Chemical & Pharmaceutical Bulletin”

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

research Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells

3 citations , September 2016 in “Natural Product Communications”

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

research Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications

4 citations , December 2013 in “Acupuncture and related therapies”

N-acetyl-cysteine shows promise in treating various diseases and may improve skin and hair conditions, but more research is needed on dosages and long-term effects.

research Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

47 citations , September 2023 in “Pharmacological Reports”

Vitamins A, B3, C, D, and E can improve skin health and immunity.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)

6 citations , May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

research Nutrition and the deleterious side effects of nutritional supplements

24 citations , June 2010 in “Clinics in Dermatology”

Taking too many vitamin and mineral supplements can cause serious health problems.

research Vitamin B-Complex and its Relationship with the Health of Vegetarian People

August 2023 in “Natural Resources for Human Health”

Vegetarians should take B vitamin supplements to avoid health issues.

Zinc in the Soil and Its Importance for Plants and Human Health: An Integrated Review

research Zinc in the Soil and Its Importance for the Plants and Human Health. An integrated review

January 2021 in “Middle East journal of applied sciences”

Zinc is essential for plant growth and human health, but many soils lack enough zinc, affecting crops and potentially leading to health problems.

research The potential involvement of cholinergic system in finasteride induced cognitive dysfunction

November 2020 in “Psychoneuroendocrinology”

Finasteride might affect memory by impacting cholinergic system.

Volatile Signaling by Sesquiterpenes from Ectomycorrhizal Fungi Reprograms Root Architecture

research Volatile signalling by sesquiterpenes from ectomycorrhizal fungi reprogrammes root architecture

193 citations , February 2015 in “Nature Communications”

Fungi-produced compounds can change plant root growth.

research Finasteride

86 citations , July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

research Zinc deficiency and its management in the pediatric population: A literature review and proposed etiologic classification

75 citations , May 2013 in “Journal of the American Academy of Dermatology”

Zinc deficiency in children can cause skin issues and can be serious if not diagnosed and treated properly.

The Dihydrotestosterone Hypothesis of Prostate Cancer and Its Therapeutic Implications

research Novel agents for the treatment of alopecia

29 citations , December 1998 in “Seminars in Cutaneous Medicine and Surgery”

New treatments for hair loss show promise, especially finasteride for men and a stronger minoxidil formula.

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process

27 citations , February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.