research Carbobenzoxy-capped Phe-Lys(BODIPY TMR-X-acyloxymethyl ketone(QSY7)
Near-infrared probes can safely and effectively image cysteine protease activity for disease diagnosis.
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research Multistage Transdermal Nitric Oxide Delivery System for the Efficient Treatment of Androgenic Alopecia
The new nitric oxide delivery system may effectively treat hair loss by improving hair follicle health and reducing inflammation.
research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond
The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.
research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies
Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.
![Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase](/images/research/d19df8a7-8de6-4430-8a0d-4ffa1f502985/small/15608.jpg)
research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase
New compounds were made that effectively block a specific enzyme related to androgen conditions.
research Biochemical and histological effects of feeding thermally oxidized rapeseed oil and lard to rats.
Feeding rats oxidized rapeseed oil and lard caused weight loss, organ damage, and toxicity symptoms.
research Assessment of Nitric Oxide Synthase Protein Level in the Scalp of Androgenetic Alopecia
Higher nitric oxide synthase levels in the scalp may influence hair loss in androgenetic alopecia.
research Alternative synthesis of the anti-baldness compound RU58841
A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
research Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development
Fatty acid transport protein 4 is essential for skin and hair development.
research GC-MS Fatty Acid Profile and In silico Studies of Telfairia occidentalis Hook f. (Fluted Pumpkin) and Sphenostylis stenocarpa (African Yam bean) Seeds Oil on Human 5 Alpha Reductase II
Compounds in fluted pumpkin and African yam bean seed oils may help manage benign prostate hyperplasia.
research Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance
Darkened knuckles can be an early sign of insulin resistance.
research Novel azaandrostane derivatives for the synthesis of 17β‐(N‐tert‐butyl carbamoyl)‐4‐aza‐5α‐androst‐1‐ene‐3‐one
A new method to make finasteride for hair loss treatment was developed.
research Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis
A new engineered treatment shows promise in curing heart fibrosis.
research Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications
Nanofat shows promise for facial rejuvenation and treating skin issues but needs more research for long-term safety.
research Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats
Inhibiting certain enzymes made female rats more sensitive to low-level pain.
research Novel amino acid‐based surfactant for silicone emulsification and its application in hair care products: a promising alternative to quaternary ammonium cationic surfactants
N‐AOHPA is a promising alternative to traditional surfactants for better hair conditioning.
research Associations of Omega-3 (n-3) Fatty Acids With Male Pattern Hair Loss Improvement: A Prospective Cohort Study
Omega-3 fatty acids may not help and could harm hair loss improvement in middle-aged or elderly men.
research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes
Researchers made two new compounds that could be used for medicine.
research Alpha linolenic acid and linoleic acid and their effects on therapeutic regimen of canine dermatoses
Alpha linolenic acid and linoleic acid help treat inflammatory skin conditions in dogs.
research SAT-130 Estrogen deficiency in patients with reduced fat mass as a cause of non-alcoholic fatty liver disease
Low estrogen due to poor nutrition can lead to non-alcoholic fatty liver disease.
research Tissue fibrosis associated depletion of lipid‐filled cells
Fibrosis causes loss of important fat cells, affecting tissue function.
research Forsythiaside A Activates AMP-Activated Protein Kinase and Regulates Oxidative Stress via Nrf2 Signaling
Forsythiaside A helps protect cells and liver from damage by reducing oxidative stress and boosting antioxidants.
research Studies on synthesis of finasteride
The new method for making finasteride is cheaper and gives a higher yield.
research Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors
Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.
research ENHANCEMENT OF FOLLICULAR DELIVERY OF FINASTERIDE IN NIOSOMALAND PRONIOSOMAL GEL FORM FOR TREATING ANDROGENETIC ALOPECIA
Finasteride, a hair loss treatment, works better and is more stable when delivered through specially prepared gels, leading to increased hair growth.
research Cholesterol and Phospholipid-free Multilamellar Niosomes Regulate Transdermal Permeation of a Hydrophobic Agent Potentially Administrated for Treating Diseases in Deep Hair Follicles
Cholesterol- and phospholipid-free niosomes improve deep skin drug delivery.
research FCE 28260, a new 5α-reductase inhibitor: In vitro and in vivo effects
FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.
research Nitrogen Mustard Induces DNA Damage and Structural Changes in Mouse Skin Hair Follicles
Nitrogen mustard causes DNA damage and structural changes in mouse skin hair follicles, but some recovery occurs after 5 days.
research Abstract: The Use of Nanofat in Androgenic Alopecia. a Prospective Blinded Study
Nanofat injections can significantly improve hair growth in men with hair loss for up to a year.
research Preparation of finasteride by selective dehydrogenation using IBX
The method produces finasteride with a 92% yield.