57 citations
,
December 2021 in “Nature Communications” Non-canonical Wnt signaling helps intestinal stem cells move to injury sites for tissue repair.
11 citations
,
October 2017 in “Oncotarget” Gsdma3 affects hair growth by controlling Wnt5a, which influences hair cell development.
September 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Special gut cells help stem cells move to and fix injured areas by activating a specific signaling pathway.
April 2010 in “Cancer Research” Mcl-1 can activate Wnt signaling in skin cells, promoting growth and possibly cancer.
5 citations
,
January 2016 in “Journal of Molecular Histology” Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.
72 citations
,
April 2008 in “Organogenesis” Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.
23 citations
,
January 2018 in “International Journal of Molecular Medicine” Baicalin helps hair growth by activating specific cell signals and pathways.
April 2017 in “Journal of Investigative Dermatology” A virus protein can activate a pathway that may lead to abnormal hair follicle development.
5 citations
,
October 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Aging hair follicle stem cells can be rejuvenated by inhibiting Cdc42.
29 citations
,
September 2012 in “Birth Defects Research” Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.
October 2020 in “Research Square (Research Square)” Aging-related changes in hair follicle stem cells can be partially reversed with a specific treatment.
19 citations
,
January 2013 in “International journal of medical sciences” Increasing Wnt5a in mice skin delays hair growth but doesn't stop it.
156 citations
,
October 2012 in “Seminars in Cell & Developmental Biology” Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
4 citations
,
January 2025 in “The Journal of Cell Biology” Ceramide Synthase 4 is crucial for maintaining hair follicle stem cells and preventing hair loss.
24 citations
,
March 2021 in “Frontiers in Cell and Developmental Biology” Wnt signaling is disrupted in asthma, affecting cell growth and inflammation.
21 citations
,
January 2023 in “The International Journal of Developmental Biology” The Wnt signaling pathway is crucial for regeneration and could help advance human medicine.
9 citations
,
January 2023 in “International Journal of Biological Sciences” CTHRC1 is essential for healing and preventing heart rupture after a heart attack.
16 citations
,
February 2014 in “Journal of Investigative Dermatology” Researchers developed a mouse model that tracks hair growth using bioluminescence, improving accuracy in studying hair cycles.
24 citations
,
August 2021 in “Scientific Reports” Non-thermal plasma could help hair growth by activating key cell signals.
April 2017 in “Journal of Investigative Dermatology” Dermal Wnt/β-catenin signaling is important for the proper size and development of hair follicles.
July 2023 in “Current Issues in Molecular Biology” Escin may help treat hair loss by boosting a specific cell growth pathway.
1 citations
,
January 2023 in “Burns & Trauma” Wnt4 protein makes the outer skin layer thicker in burn wounds by turning on a specific healing pathway and loosening the connections between skin cells.
95 citations
,
January 2012 in “British Journal of Dermatology” Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
556 citations
,
September 2008 in “Genes & Development” Wnt signaling is vital for cell growth, development, and cancer research.
173 citations
,
January 2014 in “Nature Cell Biology” Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.
May 2018 in “Journal of Investigative Dermatology” Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.
16 citations
,
January 2016 in “International Journal of Medical Sciences” Wnt5a slows down hair growth by blocking a specific pathway during hair regeneration.
2 citations
,
November 2023 in “Biomolecules” WNT signaling is crucial for skin development and healing.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
55 citations
,
September 2014 in “Development” Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.