research New agents for cancer chemoprevention
Over 30 potential cancer prevention treatments are being tested, with some showing promise in early research.
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research Safety, tolerability, and pharmacokinetics of CG2001 in Chinese adult male subjects with androgenetic alopecia: a randomized, double-blind, placebo-controlled, single- and multi-doses, phase 1 clinical study
CG2001 is safe and well-tolerated for treating hair loss in men.
research America - A Diversity of Life Styles.
The drug showed promise in treating renal cell carcinoma with manageable side effects.
research Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue
research A machine learning and network framework to discover new indications for small molecules
A machine learning model called CATNIP can predict new uses for existing drugs, like using antidepressants for Parkinson's disease and a thyroid cancer drug for diabetes.
research LB1101 Evaluating the cardiovascular safety of low-dose oral minoxidil in patients with non-scarring alopecia: A retrospective cohort study
Low-dose oral minoxidil is safe for the heart in the short term for hair loss patients.
research Methodologic considerations in evaluating early clinical outcomes of GT20029 for androgenetic alopecia
GT20029 showed some hair growth improvement, but longer studies are needed for better results.
research A decade of hair-loss clinical trials: a registry-based analysis of studies registered on ClinicalTrials.gov
Hair-loss trials have increased, but need more diverse participants and standardized measures.
research Significant effects of mild endogenous hormonal changes in humans: considerations for low-dose testing.
Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.
research Case reports and anecdotal evidence
Case reports are crucial for identifying new medical conditions and improving knowledge retention.
research Acute and 30-day oral toxicity studies of a novel coccidiostat – ethanamizuril
Ethanamizuril is safe for rats at 20 mg/kg feed, but higher doses cause hair loss, organ changes, and liver, kidney, and lung damage.
research Skin toxicity determined in vitro by three-dimensional, native-state histoculture.
This model can replace animal testing for quick, cost-effective skin toxicity tests.
research Determination of Finasteride in Human Plasma by LC/MS/MS and Study on Its Pharmacokinetics
The method accurately measures finasteride in plasma and is suitable for clinical use.
research Clinical and analytical evaluation of LC-MS methods for plasma renin activity and aldosterone
The study developed methods to measure biomarkers in mice and found differences in hormone levels linked to gut microbiota diversity and stress response.
research The difficulty of finding ‘healthy’ volunteers
Most people who volunteered for a health study had medical issues, showing the need for careful screening before trials.
research Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069.
LGD1069 effectively prevents breast tumors in mice without toxicity.
research Enhancing dermatology clinical trials: optimizing sites and strategies for success in India
India is ideal for dermatology trials due to diverse patients and cost-effectiveness.
research Evaluation of noninvasive biospecimens for transcriptome studies
Hair follicles and urine cell pellets are promising for transcriptome studies due to consistent quality and useful expression profiles.
research Safety and tolerability of low-dose oral minoxidil in adolescents: A retrospective review
The safety and tolerability of low-dose oral minoxidil for treating hair loss in adolescents is not clearly determined.
research Case-Only Trees and Random Forests for Exploring Genotype-Specific Treatment Effects in Randomized Clinical Trials with Dichotomous End Points
Case-only trees and random forests improve predictions of treatment effects in clinical trials.
research CG210 Enables Finasteride 1mg Users to Further Improve Hair Pattern: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
The document does not provide information about hair loss treatment.
research Preclinical studies of a novel polyherbal phyto–complex hair growth promoting cream
The herbal cream was found to be a safe and effective alternative for hair growth, similar to minoxidil.
research 50570 Irritation and sensitization potential of approved topical and transdermal delivery systems – A retrospective study
Generic topical and transdermal systems usually cause minimal irritation or sensitization.
research Peer Review #2 of "Computational drug repositioning based on side-effects mined from social media (v0.2)"
The peer review highlighted the need for clearer data handling, questioned the study's validity, and recognized improvements from the original version.
research DRUG NEWS
The FDA approved a new breast cancer treatment, found flu shots may reduce heart risks, questioned the safety of fast-tracked drug approvals, showed statins don't help with certain pneumonia, and approved a new dementia imaging agent.
research Cortisol determination in hair and faeces from domestic cats and dogs
Hair cortisol can reliably indicate chronic stress in cats and dogs.
research Production of ultraviolet-light-induced skin erythema in the hairless rat: a comparison with the haired rat in screening for anti-inflammatory drugs
Hairless rats are good for testing anti-inflammatory drugs, similar to haired rats, without needing to remove fur.
research AnnoPharma: Detection of substances responsible of ADR by annotating and extracting information from MEDLINE abstracts
AnnoPharma effectively identifies substances causing adverse drug reactions in medical abstracts.
research Where it all went right
Some drugs have gained approval for new uses, while others like tricyclic antidepressants and aspirin show promise but aren't yet approved for these uses.
research Hepatic and renal impairment and degenerative changes caused by carbon black nanoparticles in mice
Carbon black nanoparticles can harm liver and kidney function in mice.