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GlossaryNorethisterone

synthetic hormone used in birth control and hormone therapy

Norethisterone, also known as norethindrone, is a synthetic form of the hormone progesterone. It is commonly used in hormonal contraceptives and hormone replacement therapy to regulate menstrual cycles, treat endometriosis, and manage symptoms of menopause.

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research The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin levels: A secondary study from the WHICH randomized clinical trial

4 citations , August 2024 in “PLoS ONE”

Both injectable contraceptives lower testosterone and SHBG levels, with NET-EN having a greater effect than DMPA-IM.

research The efficacy of an adjuvant norethisterone (jenapharm) therapy in endometrial cancer

January 1987 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

Norethisterone (jenapharm) therapy is effective for endometrial cancer.

research Combined hormonal contraception and venous thromboembolism

46 citations , January 2007 in “The European Journal of Contraception & Reproductive Health Care”

Birth control pills increase the risk of blood clots, especially within the first year and with certain types.

research The effects of synthetic 19-norprogestins on osteoblastic cell function are mediated by their non-phenolic reduced metabolites

13 citations , May 2007 in “Journal of Endocrinology”

Synthetic 19-norprogestins promote bone cell growth and function through their non-phenolic metabolites.

research Progestogens in menopausal hormone therapy

10 citations , January 2015 in “Przeglad Menopauzalny”

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Use of Combined Oral Contraceptives and Risk of Venous Thromboembolism in Young Women: A Nested Case-Control Analysis Using German Claims Data

research Use of combined oral contraceptives and risk of venous thromboembolism in young women: a nested case–control analysis using German claims data

3 citations , July 2022 in “BJOG: An International Journal of Obstetrics and Gynaecology”

Some birth control pills increase young women's risk of blood clots more than others.

research A clinico-pathological study of Neogynon as a new oral contraceptive steroid.

2 citations , March 1976 in “PubMed”

Neogynon effectively prevents pregnancy but may cause side effects like headaches and menstrual changes.

research Sex hormones and related compounds, including hormonal contraceptives

January 2014 in “Side effects of drugs annual”

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

research Inhibition of skin 5α-reductase by oral contraceptive progestinsin vitro

78 citations , January 2000 in “Gynecological Endocrinology”

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

research Comparison of a gonadotropin-releasing hormone agonist and a low dose oral contraceptive given alone or together in the treatment of hirsutism.

62 citations , December 1995 in “The Journal of Clinical Endocrinology & Metabolism”

Combining a GnRH agonist with a low-dose oral contraceptive is more effective and safer for treating hirsutism than using either alone.

research Effect of a combination of ethinylestradiol and desogestrel in adolescents with oligomenorrhea and ovarian hyperandrogenism

5 citations , July 1987 in “European Journal of Obstetrics & Gynecology and Reproductive Biology”

The treatment temporarily improved symptoms of hyperandrogenism in adolescents.

research Sex Hormones: Hormonal Contraception and Hormone Replacement Therapy

2 citations , January 2019

Hormonal contraceptives and therapies regulate organ functions and treat various conditions.

Prostate-Sparing Effects in Primates of the Potent Androgen 7α-Methyl-19-Nortestosterone: A Potential Alternative to Testosterone for Androgen Replacement and Male Contraception

research Prostate-Sparing Effects in Primates of the Potent Androgen 7α-Methyl-19-Nortestosterone: A Potential Alternative to Testosterone for Androgen Replacement and Male Contraception1

14 citations , December 1998 in “The Journal of Clinical Endocrinology and Metabolism”

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

research [PRACTICAL EXPERIENCES WITH OVULATION INHIBITION].

January 1965 in “PubMed”

Ovulation inhibitors effectively treat menstrual issues and improve fertility but can have side effects.

research [Clinical findings with a low-dosed antiandrogene (cyproteronacetate) and aethinyloestradiol women with virilising symptoms (author's transl)].

3 citations , April 1977 in “PubMed”

The treatment improved acne, seborrhoea, and hirsutism, with some side effects like spotting and nervousness.

research Estranys matins de febrer: Pauline Fondevila

January 2006 in “Benzina: Revista d'excepcions culturals”

Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.

New Progesterone Esters as 5α-Reductase Inhibitors

research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.

22 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

research Studies of the components of an oral contraceptive agent in albino rats. II. Progestogenic component and comparison of effects of the components and the combined agent

24 citations , July 1980 in “Journal of Toxicology and Environmental Health”

High doses of norethindrone acetate in rats caused various organ changes but didn't significantly increase tumor rates.

research Dienogest

64 citations , January 1998 in “Drugs”

Dienogest combined with ethinylestradiol is a highly effective birth control that improves menstrual symptoms and has manageable side effects.

research Antiandrogenic progestins for treatment of signs of androgenisation and hormonal contraception

17 citations , January 2004 in “European journal of obstetrics, gynecology, and reproductive biology/European journal of obstetrics & gynecology and reproductive biology”

Certain hormone medications can treat symptoms like acne and unwanted hair, regulate periods, and prevent pregnancy in women and teenage girls.

research Progestogens with Antiandrogenic Properties

164 citations , January 2003 in “Drugs”

research News & Notes

May 2008 in “Trends in Urology Gynaecology & Sexual Health”

Loop diuretics may double bone loss in elderly men, finasteride lowers prostate cancer risk but may increase high-grade tumors, abarelix reduces testosterone quickly, and transdermal testosterone offers minimal sexual benefit for women.

research Male hormonal contraception: looking back and moving forward

23 citations , October 2015 in “Andrology”

New male hormonal contraceptives show promise but need more research on long-term effects and funding for larger trials.

research An Open Randomized Comparative Study of an Oral Contraceptive Containing Ethinyl Estradiol and Cyproterone Acetate with and without the GnRH Analogue Goserelin in the Long-Term Treatment of Hirsutism

18 citations , March 2010 in “Gynecologic and obstetric investigation”

The oral contraceptive alone is the preferred treatment for hirsutism, as adding the GnRH analog showed no significant benefit.

research Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats

1 citations , January 2013 in “UNICA IRIS Institutional Research Information System (University of Cagliari)”

Hormonal contraceptives may reduce social behavior and sexual motivation by lowering allopregnanolone levels.

The Combination of Ethinylestradiol/Cyproterone Acetate Is Temporarily Withdrawn from the Market in France. Is the Measure Justified?

research The combination of ethinylestradiol/cyproterone acetate is temporarily withdrawn from the market in France. Is the measure justified?

1 citations , March 2013 in “The European Journal of Contraception & Reproductive Health Care”

The paper suggests that France's suspension of Diane-35 was hasty and could cause treatment issues and unintended pregnancies, recommending a re-evaluation and better patient information.

research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors

13 citations , January 2005 in “Chemical and Pharmaceutical Bulletin”

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

research Die kontrazeptive Betreuung androgenisierter Frauen mit einem niedrig dosierten cyproteronacetathaltigen Einphasenpräparat

18 citations , September 1979 in “DMW - Deutsche Medizinische Wochenschrift”

Diane is effective for treating acne, seborrhoea, androgenic alopecia, and mild hirsutism in women.

research Levonorgestrel effects on serum androgens, sex hormone–binding globulin levels, hair shaft diameter, and sexual function

20 citations , April 2009 in “Fertility and Sterility”

research Contraceptive implants considered 'safe'

March 2002 in “Reactions Weekly”

Some birth control pills increase blood clot risk; use them for specific conditions only.