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New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Vitamin D and its receptor may help prevent skin cancer.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.

ΔNp63α helps control a protein that stops cancer cells from spreading.

Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.

A specific gene mutation causes congenital hair loss.

Researchers created a mouse model of a type of rickets that does not cause hair loss.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

The vitamin D receptor can affect gene activity even without its usual hormone in hair and skin.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

TLR4 is important in aging-related diseases and could be a new treatment target.

Acne is caused by multiple factors including oil production, bacteria, inflammation, and possibly diet and environment.

Vitamin D3 may protect rat hair follicles from radiation damage.

Mice without active or present vitamin D receptors maintain normal blood sugar control and islet gene expression when calcium levels are normal.

PPAR β/δ is important for skin health and disease treatment, but more research is needed.

A new gene mutation causes vitamin D-resistant rickets and hair loss in two siblings.

Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.

Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

RXRa is crucial for Th2 immune cell development and may link nutrition to immune health.

α-Mangostin can naturally lighten skin by reducing melanin.

RORA may help regulate hair growth by affecting hair follicle stem cells.