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GlossaryNuclear Translocation

process where molecules move from cytoplasm to nucleus

Nuclear translocation refers to the process by which molecules, such as proteins or transcription factors, move from the cytoplasm of a cell into its nucleus. This movement is crucial for regulating gene expression, as these molecules often need to interact with DNA to activate or repress specific genes. For example, in the context of hair biology, certain signaling proteins might undergo nuclear translocation to influence the growth and health of hair follicles.

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research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation

25 citations , October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.

research Detection of the nuclear translocation of androgen receptor using quantitative and automatic cell imaging analysis

December 2024 in “Tissue and Cell”

A new method helps detect androgen receptor movement in cells, aiding research on hair loss treatments.

Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

research Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

57 citations , January 2013 in “International Journal of Medical Sciences”

Lef1 helps stem cells become hair cells by interacting with specific signaling pathways.

research Cyclosporine A increases hair follicle growth by suppressing apoptosis-inducing factor nuclear translocation: a new mechanism

9 citations , January 2015 in “Fundamental & clinical pharmacology”

Cyclosporine A helps hair grow by blocking a process that would otherwise cause hair cells to die.

A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

91 citations , May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

research Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome

34 citations , July 2020 in “American journal of human genetics”

Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.

research Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers

15 citations , May 2017 in “Journal of Cellular Biochemistry”

The hairless protein is important for skin, hair, and may influence cancer development.

research Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

14 citations , September 2018 in “International Journal of Molecular Sciences”

Mackerel-derived fermented fish oil helps hair grow by activating growth pathways and increasing cell proliferation.

Regulatory Effect of Beta-Catenin on Proliferation of Hair Follicle Stem Cells Involves PI3K/Akt Pathway

research Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway

11 citations , March 2013 in “Journal of Applied Biomedicine”

β-catenin helps hair follicle stem cells grow by activating a specific cell pathway.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

research Functional analysis of vitamin D receptor (VDR) using adenovirus vector

4 citations , February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

research PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells

2 citations , July 2024 in “Bioengineering”

PRF lysates reduce inflammation in cancer cells and boost immune response in healthy oral cells.

research Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway

February 2025 in “Frontiers in Veterinary Science”

Certain nutrients like keratin, egg yolk, and fish collagen may help pets regrow hair.

research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo

52 citations , May 1997 in “Journal of Biological Chemistry”

High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.

research Targeting receptor–regulator interactions

August 2013 in “Nature Reviews Drug Discovery”

New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.

A New Way to Restore Tumor Suppressor Function

research A new way to restore tumour suppressor function

August 2013 in “Nature Reviews Drug Discovery”

New treatments may restore cancer-blocking proteins, slow prostate cancer, identify drug targets, and potentially regrow hair.

research Effects of the androgen receptor overexpression in prostate cancer

October 2013

Androgen receptor overexpression can increase prostate cancer cell growth even without hormones.

research Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

42 citations , July 2017 in “Molecular therapy”

A form of vitamin E promotes hair growth by activating a specific skin pathway.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Effects of dihydrotestosterone on rat dermal papilla cells in vitro

19 citations , April 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

research Regulation of Hair Shedding by the Type 3 IP3 Receptor

19 citations , May 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

The type 3 IP3 receptor is important for controlling hair loss and growth.

research Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling

11 citations , August 2021 in “Stem Cell Research & Therapy”

Pimecrolimus reduces the effectiveness of stem cell therapy for atopic dermatitis.

Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review

research miR‐200a‐3p in Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Attenuates UVB‐Induced Skin Inflammatory Response and Oxidative Stress via Keap1‐Nrf2 Pathway

January 2025 in “Stem Cells International”

Exosomes from stem cells can reduce UV-induced skin damage by lowering inflammation and oxidative stress.

CRABP1 Enhances Proliferation of Dermal Papilla Cells in Hu Sheep via Wnt/β-Catenin Pathway

research CRABP1 Enhances the Proliferation of the Dermal Papilla Cells of Hu Sheep through the Wnt/β-catenin Pathway

September 2024 in “Genes”

CRABP1 boosts hair cell growth in Hu sheep by affecting key genes.

research 778 Designing and utilizing a c-Rel specific bioassay in drug repurposing screen for HNSCC

July 2024 in “Journal of Investigative Dermatology”

A new test helps find drugs to treat head and neck cancer by targeting c-Rel.