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Search for New Antineoplastic Agents Based on Structural Modifications of Steroidal 5α-Reductase, 17β-Hydroxysteroid Dehydrogenase, and 17α-Hydroxylase/17,20-Lyase Inhibitors

research Search for New antineoplastic agents based on structural modifications of steroidal 5α-reductase, 17β-hydroxysteroid dehydrogenase, and 17α-hydroxylase/17,20-lyase inhibitors

November 2025 in “Russian Journal of Oncology”

Modifying steroidal inhibitors shows promise for developing new cancer treatments.

research Polynucleotides in aesthetic medicine: the science, mechanisms and clinical considerations

January 2026 in “Journal of Aesthetic Nursing”

Polynucleotides improve skin quality and are safe and effective for rejuvenation.

research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

November 2023

New steroid derivatives show promise as anticancer agents, even against resistant cells.

research 525 Aptamer-Based Targeted Therapy for wound healing and hair growth promotion

November 2024 in “Journal of Investigative Dermatology”

Aptamers can improve wound healing and promote hair growth.

research Synthesis, antiproliferative activity, acute toxicity and assessment of the antiandrogenic activities of new androstane derivatives

10 citations , July 2011 in “Archives of Pharmacal Research”

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research Patent Evaluation: Δ-4,6-Steroids as Potent 5α-Reductase Inhibitors

April 1992 in “Current opinion in therapeutic patents”

New steroids were patented as effective for treating acne, hair loss, and other conditions related to hormones.

research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines

12 citations , February 2010 in “Tetrahedron Letters”

New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research Nanoliposomal Co-Delivery of AR-PROTAC and NFKBIZ siRNA for Synergistic Therapy of Androgenetic Alopecia

January 2026 in “ACS Applied Bio Materials”

A new treatment using nanoliposomes can improve hair regrowth in androgenetic alopecia.

research Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2

October 2021

Cepharanthine and tetrandrine show promise as COVID-19 drugs.

research Novel type 1 5a-reductase Inhibitors with Antiproliferative Potential on LNCaP cells

June 2023 in “Oriental Journal of Chemistry/Oriental journal of chemistry”

New compounds may help treat prostate cancer by reducing cell growth.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

research Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

December 2023 in “Journal of Medicinal Chemistry”

A new topical treatment for hair loss shows strong hair growth effects with low toxicity.

research Molecular Interactions of New Pregnenedione Derivatives

20 citations , January 2003 in “Chemical and Pharmaceutical Bulletin”

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

Synthesis of Analogues of Cercidin, an Antimicrobial Compound of Cercidiphyllum Japonicum: Glycosylation of Methyl Gallate with Ulosyl Bromides

research Synthesis of Analogues of Cercidin, an Antimicrobial Compound of Cercidiphyllum japonicum : Glycosylation of Methyl Gallate with Ulosyl Bromides

June 2025 in “Natural Product Communications”

Researchers created 10 new compounds similar to cercidin, which could lead to new antibiotics.

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research Non-competitive androgen receptor inhibition in vitro and in vivo

January 2010 in “Yearbook of Endocrinology”

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

research The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review

17 citations , December 2024 in “Journal of Cosmetic Dermatology”

Polynucleotides might work well in esthetic medicine, but more research is needed.

research Nano-PROTACs: state of the art and perspectives

51 citations , January 2024 in “Nanoscale”

Nano-PROTACs could improve drug targeting and delivery by using nanotechnology.

research NEW NON SYNTHETIC MOLECULES ARE ABLE TO INHIBIT APOPTOSIS IN DERMAL PAPILLAR CELLS OF HAIR BULB

January 2011 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

New molecules can prevent cell death in hair follicles.

research Comparison of Efficacy and Specificity in Cancer‐Targeting Prodrug Conjugates

1 citations , May 2022 in “The FASEB journal”

The document concludes that biotin, folate, and RGD peptides are promising for targeting cancer cells with prodrugs, but the conjugates are not yet tested for use.

research Targeting Solid Tumours With Potassium Channel Activators. A Return to Fundamentals?

1 citations , November 2014 in “Thérapie”

Potassium channel activators like nicotinamide and minoxidil might help treat solid tumors.

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research Anthracycline analogs The past, present, and future

168 citations , December 1986 in “Cancer Chemotherapy and Pharmacology”

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors in silico and in vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

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