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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration

April 2019 in “Journal of Investigative Dermatology”

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

research Phospholipase A₂ inhibition as potential therapy for inflammatory skin diseases

13 citations , April 2013 in “Immunotherapy”

Inhibiting PLA2 enzymes may help treat inflammatory skin diseases like psoriasis and dermatitis.

research 131 Mutational landscape of extramammary Paget disease

April 2018 in “Journal of Investigative Dermatology”

The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.

research PCA: A tFNA-based targeted nucleic acid nanocomposite hydrogel for the treatment of androgenetic alopecia through the promotion of angiogenesis and hair follicle stem cell proliferation

February 2026 in “Chemical Engineering Journal”

PCA hydrogel promotes hair growth by enhancing blood vessel formation and hair follicle stem cell activity.

research 2,5-Diazabicyclo[2.2.1]heptane in medicinal chemistry: a treasure trove of therapeutic opportunities

January 2026 in “RSC Medicinal Chemistry”

2,5-DBH shows promise for improving drugs in cancer, brain disorders, and infections.

research 290 Brepocitinib improves cicatricial alopecia and downregulates key T-helper biomarkers

July 2024 in “Journal of Investigative Dermatology”

Brepocitinib improves cicatricial alopecia and reduces key immune markers.

research Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial

March 2026 in “British Journal of Dermatology”

Deucravacitinib did not significantly improve hair regrowth in alopecia areata patients.

research Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats

March 2025 in “International Journal of Molecular Sciences”

PLIN2 affects hair growth in cashmere goats, potentially improving cashmere quality.

research A new strategy to modulate alopecia using a combination of two specific and unique ingredients.

7 citations , May 2013 in “PubMed”

A new hair loss treatment with two unique ingredients improved hair growth.

research Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice

1 citations , December 2021 in “Development & Reproduction”

Lack of FPR2 slows hair growth by affecting hair cell activity.

research Nanocarriers for Improved Delivery of Angiotensin-(1-7)

January 2015 in “Elsevier eBooks”

Nanocarriers like liposomes and cyclodextrins improve how angiotensin-(1-7) is delivered in the body.

research Two Hydroxyproline Galactosyltransferases, GALT5 and GALT2, Function in Arabinogalactan-Protein Glycosylation, Growth and Development in Arabidopsis

63 citations , May 2015 in “PloS one”

GALT5 and GALT2 are important for plant growth and development because they help with protein glycosylation.

research Antioxidant and anticancer properties of bioactive peptides from Lablab purpureus

January 2023

Lablab purpureus peptides may effectively kill cancer cells with fewer side effects.

research Complete sequence of a hair-like intermediate filament type II keratin gene

15 citations , January 1993 in “DNA sequence”

KRT2.13 gene is similar to KRT2.9 but not expressed in hair follicles.

research Isolation and Characterization of Mouse High-glycine/Tyrosine Proteins

24 citations , November 1997 in “Journal of Biological Chemistry”

Mouse high-glycine/tyrosine proteins have distinct patterns in hair follicles, peaking at specific hair cycle days.

research Molecular modeling of hair keratin/peptide complex: Using MM‐PBSA calculations to describe experimental binding results

14 citations , January 2012 in “Proteins”

Electrostatic interactions mainly stabilize the binding of peptides to hair keratin.

research Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling

148 citations , October 1997 in “Journal of Investigative Dermatology”

research Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids

13 citations , May 2021 in “FASEB bioAdvances”

Plant-based products can improve hair and skin health without harmful side effects.

research A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for Enhanced Transdermal Delivery

36 citations , August 2020 in “Polymers”

The patch delivers more drugs through the skin effectively.

research Effect of a peptide in cosmetic formulations for hair volume control

14 citations , July 2017 in “International Journal of Cosmetic Science”

The peptide effectively reduces hair volume in humid conditions, especially for Caucasian hair.

research An Androgenetic Alopecia Remedy Based on Marine Collagen Peptide-Incorporated Dissolving Microneedles

November 2023 in “International Journal of Pharmaceutics”

New hair loss treatment using marine collagen and dissolvable needles improves hair growth.

research Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

328 citations , November 2020 in “Nature Materials”

Hydrogel scaffolds can help wounds heal better and grow hair.

research Identification and sequence analysis of the keratin-associated protein 24‐1 (KAP24-1) gene homologue in sheep

51 citations , September 2012 in “Gene”

The research identified a gene in sheep important for wool quality, which could help improve wool traits.

research Characterization of the in vitro, ex vivo, and in vivo Efficacy of the Antimicrobial Peptide DPK-060 Used for Topical Treatment

78 citations , May 2019 in “Frontiers in Cellular and Infection Microbiology”

DPK-060 in poloxamer gel effectively treats skin infections, but nanocarriers don't enhance its efficacy.

Endocannabinoid-Like Molecule Oleoylethanolamide Promotes Sebaceous Lipid Synthesis

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