research Nociceptive and Nonnociceptive Roles of TRPV3 and Its “Druggability”
TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.
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research Organotypic Skin Culture
Organotypic culture systems can grow skin tissues that mimic real skin functions and are useful for skin disease and hair growth research, but they don't fully replicate skin complexity.
research A consideration when interpreting outpatient data
Objective assessment is needed to accurately determine medication use and adherence.
research Integrating evidence-based lifestyle and adjunct therapies for long-term management of polycystic ovary syndrome: mechanistic insights and clinical implications
This narrative review emphasizes the importance of integrating evidence-based lifestyle and adjunct therapies for managing polycystic ovary syndrome (PCOS), a disorder affecting 6%-13% of reproductive-aged women. It highlights the potential benefits of dietary interventions, such as Mediterranean and low-glycemic index diets, and structured physical activities like aerobic and resistance training, in improving metabolic and hormonal outcomes. Adjunct strategies, including nutraceuticals and phytochemicals, may modulate insulin signaling and inflammation, while psychological interventions can enhance treatment adherence. Complementary systems like Ayurveda and Traditional Chinese Medicine are also explored. The review concludes that a balanced, individualized approach combining lifestyle strategies, pharmacological therapies, and adjunct interventions is essential for effective PCOS management, though further high-quality clinical trials are needed to validate these strategies.
research Identification of Potential Biomarkers for Diagnosis of Patients with Methamphetamine Use Disorder
Gene expression in hair follicles can help diagnose methamphetamine use disorder.
research UHPLC/Q-TOFMS-based plasma metabolomics of polycystic ovary syndrome patients with and without insulin resistance
The research found different metabolism changes in PCOS patients and suggested new potential markers for diagnosing PCOS with or without insulin resistance.
research [Peptidergic innervation in the sinus hair follicles of several mammalian species].
Sinus hair follicles in mammals have different nerve fiber types with species-specific patterns, especially in cats.
research In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond
New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.
research Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship
Certain alkaloids could help create new coronavirus drugs.
research The biology and clinical application of systemic glucocorticoids
Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.