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GlossaryCombination Therapies

use of multiple treatments simultaneously for one condition

Combination Therapies, also known as Combined Treatments, refer to the use of multiple therapeutic approaches simultaneously to treat a single condition. In the context of hair loss or alopecia, this might involve using both topical treatments like minoxidil and oral medications such as finasteride, along with other interventions like laser therapy or platelet-rich plasma (PRP) injections. This approach aims to enhance the overall effectiveness of treatment by targeting different mechanisms involved in the condition.

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research A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl’s Melanosis

36 citations , June 2016 in “Journal of dermatological treatment”

The combination therapy significantly improved Riehl’s melanosis in patients without serious side effects.

research Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata

24 citations , March 2009 in “Archives of dermatological research”

The combination of oral PUVA and corticosteroids helps regrow hair in severe alopecia areata.

Comparison of QR 678 and QR 678 Neo as Monotherapy and Combination Therapy with 5% Minoxidil Solution and Oral Finasteride in the Treatment of Male Androgenetic Alopecia—Which Is Better?

research “Comparison of QR 678 ® & QR678 ® Neo as monotherapy and as combination therapy with 5% Minoxidil solution and oral Finasteride in the treatment of male androgenetic alopecia—Which is better?”

3 citations , April 2021 in “Journal of Cosmetic Dermatology”

Combination therapy with QR 678 Neo and 5% Minoxidil is most effective for male hair loss.

research Combination therapy with oral minoxidil and dutasteride in the treatment of male patterned baldness: A case report

January 2022 in “Cosmoderma”

Using oral minoxidil and dutasteride together can quickly increase hair growth and volume with minimal side effects.

Comparative Study of a Topical and Oral Combination Therapy Containing Oleanolic Acid, Apigenin, and Biotinyl Tripeptide-1 in Patients with Androgenetic Alopecia: A Prospective, Open-Label Trial

research Comparative Study of a Topical and Oral Combination Therapy Containing Oleanolic Acid, Apigenin, and Biotinyl Tripeptide-1 in Patients with Androgenetic Alopecia: A Prospective, Open-Label Trial

July 2025 in “Cosmetics”

The combination therapy improved hair growth and thickness in people with androgenetic alopecia.

research Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata

14 citations , January 2015 in “Annals of dermatology/Annals of Dermatology”

Corticosteroid pulse therapy is more effective for severe alopecia areata than combination therapy.

research Therapeutic Efficacy of Combination Therapy Using Oral Cyclosporine with a Dietary Supplement (Pantogar®) in Twenty-Nail Dystrophy

7 citations , January 2017 in “Annals of Dermatology”

Oral cyclosporine combined with Pantogar® effectively treats twenty-nail dystrophy.

research Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone

80 citations , December 2017 in “International Journal of Dermatology”

Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.

research BH06: Clinical trial of combination therapy with oral hydroxychloroquine and topical tacrolimus versus oral finasteride and topical tacrolimus in frontal fibrosing alopecia

July 2022 in “British Journal of Dermatology”

research A systematic review of clinical trials using single or combination therapy of oral or topical finasteride for women in reproductive age and postmenopausal women with hormonal and nonhormonal androgenetic alopecia

March 2023 in “Advances in Clinical and Experimental Medicine”

Oral and topical finasteride are effective and safe for treating female hair loss.

Treatment of Androgenetic Alopecia with Low Dose Oral Minoxidil Monotherapy Compared to Combination Therapy with Dutasteride or Finasteride

research Treatment of Androgenetic Alopecia with Low Dose Oral Minoxidil Monotherapy Compared to Combination Therapy with Dutasteride or Finasteride

January 2025 in “Journal of the American Academy of Dermatology”

Low-dose oral minoxidil alone is effective for treating hair loss, but combining it with dutasteride or finasteride may offer better results.

research Improving efficacy and maintaining safety in the treatment of alopecia with low-dose oral minoxidil and spironolactone combination therapy: A retrospective review

2 citations , August 2024 in “JAAD International”

Combining low-dose oral minoxidil and spironolactone may improve hair growth safely.

research Combination Therapy to Treat Asian Female Pattern Hair Loss

January 2019 in “Journal of Cosmetics, Dermatological Sciences and Applications”

The combination therapy is safe and effective for treating Female Pattern Hair Loss in Asian women.

research Spironolactone in combination drug therapy for unresponsive hirsutism

44 citations , June 1985 in “Fertility and sterility”

Combination drug therapy is effective for hirsutism that doesn't improve with just one medication.

research Approach to Managing Recalcitrant Alopecia Areata with Combination Therapy: A Series of Five Cases in Black Pediatric Patients

January 2026 in “Journal of Dermatology Research and Therapy”

Combination therapy effectively regrows hair and reduces severity in Black children with stubborn Alopecia Areata.

research Combination of baricitinib and conventional immunomodulating therapy for alopecia totalis

July 2023 in “Skin Research and Technology”

Baricitinib combined with other immune therapies may safely and effectively treat severe scalp hair loss.

research Long-Term Response of Hirsutism and Other Hyperandrogenic Symptoms to Combination Therapy in Polycystic Ovary Syndrome

13 citations , June 2018 in “Journal of Womens Health”

Combination therapy with oral contraceptives and spironolactone improves hair growth, menstrual issues, and acne in women with PCOS.

research Efficacy of combination therapy for the management regime of Alopecia areata.

5 citations , July 2007 in “PubMed”

Combining oral prednisolone and topical minoxidil effectively reduces hair loss and promotes regrowth in alopecia areata.

research Combination therapy in female pattern hair loss

May 2023 in “Journal of Cosmetic and Laser Therapy”

Using multiple treatments together works better for female hair loss than using one treatment alone.

Primary Cicatricial Alopecia Successfully Treated with a Combination of Oral Zinc and Nd: YAG Laser: A Case Series of Five Patients

research Primary Cicatricial Alopecia Successfully Treated with A Combination of Oral Zinc with Nd: YAG Laser. A Case Series of Five Patients

1 citations , January 2020 in “ARC Journal of Dermatology”

Oral zinc and Nd:YAG laser therapy effectively treated primary cicatricial alopecia in five patients.

Oral Tofacitinib and Systemic Corticosteroids, Alone or in Combination, in Patients With Moderate-to-Severe Alopecia Areata: A Retrospective Study

research Oral Tofacitinib and Systemic Corticosteroids, Alone or in Combination, in Patients With Moderate-to-Severe Alopecia Areata: A Retrospective Study

8 citations , June 2022 in “Frontiers in Medicine”

Both individual and combined treatments of tofacitinib and corticosteroids can help regrow hair in moderate-to-severe alopecia areata, but ongoing treatment may be necessary.

research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

71 citations , January 2004 in “Dermatology”

Oral finasteride works better than topical minoxidil for hair growth, both are safe.

research Effectiveness and Safety of Combined Therapy with Oral Minoxidil, Oral Dutasteride, and Mesotherapy with Dutasteride in Real Clinical Practice

September 2025

The combination of oral minoxidil, oral dutasteride, and mesotherapy is the most effective and safe for hair growth in AGA.

research Improvement in Androgenetic Alopecia (Stage V) Using Topical Minoxidil in a Retinoid Vehicle and Oral Finasteride

23 citations , December 1995 in “Archives of Dermatology”

Combination therapy improves hair growth in advanced hair loss.

Efficacy of 5% Topical Minoxidil Versus 5 Mg Oral Biotin Versus Topical Minoxidil and Oral Biotin on Hair Growth in Men: Randomized, Crossover, Clinical Trial

research Efficacy of 5% topical minoxidil versus 5 mg oral biotin versus topical minoxidil and oral biotin on hair growth in men: randomized, crossover, clinical trial

April 2024 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

Using both minoxidil and biotin together increased hair growth more than using either one alone.