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GlossaryOrganogenesis

process where embryonic cells develop into organs and tissues

Organogenesis is the process during embryonic development where the three primary germ layers (ectoderm, mesoderm, and endoderm) differentiate and develop into the internal organs and tissues of an organism. This complex process involves cell signaling, gene expression, and tissue interactions to form structures like the heart, lungs, and liver, ensuring the proper function and organization of the body.

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research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations , April 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

research Wnt signaling in skin organogenesis

72 citations , April 2008 in “Organogenesis”

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

research Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis

4 citations , July 2022 in “Frontiers in Cell and Developmental Biology”

The document concludes that understanding adult stem cells and their environments can help improve skin regeneration in the future.

research Deconvolving organogenesis in space and time via spatial transcriptomics in thick tissues

3 citations , September 2024

3DEEP reveals early hair follicle stem cell formation and niche establishment before hair bulb development.

research Developmental and reproductive outcome of F1 generation of Wistar rats exposed to Acanthus montanus aqueous extract during organogenesis

July 2008 in “Planta Medica”

Acanthus montanus extract harms fetal development and causes infertility in offspring.

research FGF-9 accelerates epithelial invagination for ectodermal organogenesis in real time bioengineered organ manipulation

19 citations , November 2012 in “Cell Communication and Signaling”

FGF-9 speeds up the early development of certain organs, showing potential for organ regeneration.

research Skin Organogenesis and Dysmorphogenetic Factors in Skin Diseases (Review)

1 citations , December 2018 in “Sovremennye tehnologii v medicine”

Disruptions in Wnt signaling can lead to skin and hair diseases.

research SOX9 in organogenesis: shared and unique transcriptional functions

10 citations , September 2022 in “Cellular and Molecular Life Sciences”

SOX9 is essential for the development of various organs and hair follicles.

research Cytokinin improves in vitro organogenesis, biological activities and blooming in Vitex negundo L. - An endangered medicinal plant

October 2025 in “Plant Science Today”

Cytokinins help Vitex negundo grow better and bloom more.

research Inducing hair follicle organogenesis with defined environmental protein factors

September 2016 in “Journal of Dermatological Science”

Protein extract from embryonic skin can create new hair follicles in adult life, primarily through effects on fibroblasts.

research Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids

1 citations , July 2021 in “Organoid (Online)”

Organoid technology is advancing and entering commercial use, with applications in disease modeling, drug development, and personalized medicine.

research Embriología del pollo desde la puesta a la organogénesis: : soporte gráfico a la aplicación Hupercard

January 1991 in “Dialnet (Universidad de la Rioja)”

The Use of Stem Cell Differentiation Stage Factors Taken from Zebrafish Embryos During Organogenesis and Their Role in Regulating Gene Expression of Normal and Pathological Cells

research The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells

3 citations , July 2020 in “International Journal of Molecular Sciences”

SCDSFs from zebrafish embryos are beneficial for treating cancer, regenerating tissues, and improving conditions like psoriasis and alopecia.

research The Hair Follicle as a Dynamic Miniorgan

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Molecular principles of hair follicle induction and morphogenesis

479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse

232 citations , January 2002 in “Mechanisms of development”

Different enzymes are active in different parts of developing mouse organs.

research ATP-dependent chromatin remodeling during mammalian development

182 citations , August 2016 in “Development”

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

research Hair structure anatomy and comparative anatomy1 1Dedicated to the memory of the late Dr. R. E. Rivett whose untimely death prevented his role in co-authorship.

50 citations , March 2001 in “Clinics in dermatology”

Human hair is complex and grows in cycles starting from embryonic life.

research The Organizer and Beyond

9 citations , July 2001 in “Cell”

Cells from certain embryo parts can induce head formation in another embryo, involving complex signaling pathways.

research Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ

6 citations , January 2016 in “Methods in molecular biology”

Scientists have developed a new method using stem cells to grow and transplant hair follicles, which could be useful for hair regeneration treatments.

research Micropropagation of an important medicinal herb Eclipta alba (L.) Hassk.

5 citations , May 2016 in “Jahangirnagar University Journal of Biological Sciences”

Eclipta alba was successfully grown in the lab with normal growth and flowering.

research Molecular Mechanisms of Hair Follicle Development

4 citations , January 2024 in “The Scientific World JOURNAL”

Understanding hair follicle development helps create treatments for hair loss and improve hair health.

research Mechanism of Apoptotic Regulation of Follicular Regression

2 citations , June 2001 in “American Journal of Pathology”

The document concludes that understanding how hair follicles naturally die and regenerate is important for insights into organ development and could impact health and disease treatment.

research Anatomy and Biology of Hair at Different Ages

1 citations , December 2023

Hair grows in cycles and changes with age, starting from fetal development.

research Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective

December 2023 in “Aggregate”

Scientists are using clumps of special stem cells to improve organ repair.

research Hair-specific expression of chloramphenicol acetyltransferase in transgenic mice under the control of an ultra-high-sulfur keratin promoter.

33 citations , September 1990 in “Proceedings of the National Academy of Sciences”

The study showed that a specific DNA sequence can control gene expression in hair growth areas of mice.

research The fundamentals of WNT10A

6 citations , January 2025 in “Differentiation”

WNT10A is important for tissue development and linked to various human disorders.

research A novel pathogenic variant of NECTIN4 gene in a child with ectodermal dysplasia-syndactyly syndrome

January 2023 in “Indian dermatology online journal”

A child with ectodermal dysplasia-syndactyly syndrome has a new mutation in the NECTIN4 gene.

research RANK as a therapeutic target in cancer

50 citations , January 2016 in “The FEBS journal”

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.