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research Pharmacological investigation of vitamin E with combined oral contraceptives on INHBA gene against PCOS that intricate through melatonin PKC pathway

November 2023 in “Systems Biology in Reproductive Medicine”

This study investigates the effects of vitamin E combined with a combined oral contraceptive (COC) on polycystic ovary syndrome (PCOS) in female SD rats, focusing on the melatonin protein kinase C (PKC) pathway. The research utilized both in silico and in vivo methods, revealing that vitamin E and drospirenone (DRSP) have high binding affinity for the INHBA gene. In vivo results showed a significant decrease in testosterone levels and an increase in INHBA gene expression, which stimulates FSH production. The combination of vitamin E and COC was found to be beneficial against PCOS by modulating oxidative stress, influencing circadian rhythm, and affecting the melatonin PKC pathway.

research Matrix effects and application of matrix effect factor

323 citations , November 2017 in “Bioanalysis”

Matrix effects in LC-MS can be managed but not completely avoided.

research Cutaneous and Ocular Late Complications of Sulfur Mustard in Iranian Veterans

94 citations , January 2007 in “Cutaneous and Ocular Toxicology”

Iranian veterans exposed to sulfur mustard suffer from long-term skin itching and eye damage, with some risk of skin cancer and ongoing management challenges.

research Combined Systemic and Cutaneous Ovalbumin–Aluminum Sensitization Triggers Thermal Hyperalgesia, Spinal Gliosis, and Nociceptive Nerve Fibers Sprouting in Mice

1 citations , September 2025 in “Physiologia”

Ovalbumin–aluminum sensitization causes increased pain sensitivity and nerve changes in mice.

Polycystic Ovaries: A Cross-Sectional Study on Unmarried Girls in Saudi Arabia

research Polycystic Ovaries: A Cross Sectional Study on Unmarried Girls in KSA

January 2023 in “Austin Journal of Obstetrics and Gynecology”

PCOS affects many young women in KSA, with mild cases being most common.

research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines

12 citations , February 2010 in “Tetrahedron Letters”

New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.

research Sulfur Containing Tyrosine Analogs Can Cause Selective Melanocytotoxicity Involving Tyrosinase-Mediated Apoptosis

16 citations , September 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

research Potassium channel openers: pharmacological and clinical aspects

119 citations , October 1992 in “Fundamental & Clinical Pharmacology”

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

research A new catalyst for organic synthesis: mercuric triflate

72 citations , December 2009 in “Organic and Biomolecular Chemistry”

Mercuric triflate is an effective catalyst for various organic reactions, working well at room temperature with high yields.

research The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin

14 citations , July 2015 in “International Journal of Molecular Sciences”

S-Methylmethionine sulfonium can protect skin from UVB damage.

research Clinical management of patients withASXL1mutations and Bohring-Opitz syndrome, emphasizing the need for Wilms tumor surveillance

56 citations , April 2015 in “American journal of medical genetics. Part A”

Patients with Bohring-Opitz syndrome and ASXL1 mutations need regular kidney ultrasounds to check for tumors.

research Composite materials based on metal-organic frameworks loaded with effective therapeutic components for promoting wound healing

January 2026 in “Frontiers in Materials”

Metal-organic frameworks help heal wounds by effectively delivering medicine.

research Novel causes of drug-induced occupational asthma

4 citations , July 2018 in “The Journal of Allergy and Clinical Immunology: In Practice”

Four new substances—minoxidil, ferrimanitol ovalbumin, clarithromycin, and glucosamine-hydrochloride—can cause occupational asthma.

TWEAK-Conjugated Selenoviologen as a Novel Photosensitizer for Selective Wound Accumulation and Synergistic Healing of Drug-Resistant Bacterial Infections

research TWEAK-conjugated selenoviologen as a novel photosensitizer for selective wound accumulation and synergistic healing of drug-resistant bacterial infections

March 2026 in “Science China Materials”

SeV-Tp speeds up healing of drug-resistant infections by targeting wounds and killing bacteria with light activation.

research SIMULTANEOUS ESTIMATION OF MINOXIDIL AND FINASTERIDE BY RP-HPLC IN PRESENCE OF SOY LECITHIN EXCIPIENT IN THE LOTION DOSAGE FORM

January 2018 in “Journal of analytical, bioanalytical and separation techniques”

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

research Ultrastructural localization of hair keratins, high sulfur keratin-associated proteins and sulfhydryl oxidase in the human hair

9 citations , February 2016 in “Anatomical Science International”

Hair proteins change location and structure as hair cells mature.

research Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome (PCOS)

19 citations , January 2019 in “Ginekologia Polska”

The combined Myo-inositol and D-chiro-inositol treatment improved weight, hormone levels, and skin conditions in women with PCOS.

Steroid Sulfatase Inhibitors: Therapeutic Applications and Development

research Steroid sulfatase inhibitors

25 citations , May 2003 in “Expert Opinion on Therapeutic Patents”

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

65 citations , March 2004 in “Journal of Clinical Investigation”

Inhibiting ornithine decarboxylase may help prevent certain skin cancers.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Investigation of intermolecular interactions in finasteride drug crystals in view of X-ray and Hirshfeld surface analysis

16 citations , July 2015 in “Journal of Molecular Structure”

Finasteride crystals are held together by hydrogen bonds and weak interactions, forming synthon pseudopolymorphs.

research Assessment of ultrasonographic features of polycystic ovaries is associated with modest levels of inter-observer agreement

39 citations , January 2009 in “Journal of Ovarian Research”

Observers often disagree on ultrasound results for polycystic ovaries, needing better training for consistency.

research CERTAIN PHASES OF SULFUR METABOLISM OF THE SKIN

15 citations , October 1936 in “Archives of Dermatology”

Cystine is crucial for forming keratin in hair, wool, and nails.

research Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues

2 citations , November 2022 in “Bioscience Reports”

Polycystic ovary syndrome and iron overload share similar symptoms and can be potentially treated with blood removal, diet changes, and probiotics.

research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor

116 citations , December 2003 in “Acta Dermato Venereologica”

Iressa often causes skin issues like acne and dryness in lung cancer patients.

research Molluscum Contagiosum in an Epidermoid Cyst

9 citations , June 2011 in “American Journal of Dermatopathology”

Molluscum contagiosum can occur in epidermoid cysts, especially with prolonged steroid use.

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