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research Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

12 citations , January 1987 in “Carcinogenesis”

TCDD changes skin cell growth and keratin production in mice.

research Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells

133 citations , March 1999 in “Journal of Cutaneous Pathology”

Trichoepitheliomas and some basal cell carcinomas likely come from hair follicle stem cells.

research Evidence of proliferative activity in human Merkel cells: implications in the histogenesis of Merkel cell carcinoma

12 citations , November 2018 in “Archives of Dermatological Research”

The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-Autonomous and Non-Cell-Autonomous Tumor Suppressor Activity in Mouse Epidermis

research The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis

28 citations , July 2007 in “Development”

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

Integrating Single-Cell and Spatial Transcriptomics of Human Hair Follicles to Define Transcriptional Signature of Follicular Dermal Papilla

research 189 Integrating single-cell and spatial transcriptomics of human hair follicles to define transcriptional signature of follicular dermal papilla

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The research identified specific genes that are active in the cells crucial for hair growth.

research Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

February 2022 in “Research Square (Research Square)”

High TSPEAR levels in colorectal cancer predict worse outcomes.

research Hair Cycle-Dependent Expression of Hepatocyte Growth Factor (HGF) Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of HGF in Rat Hair Follicles

33 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

research Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes

27 citations , February 2003 in “European Journal Of Oral Sciences”

SVpgC2a cells show abnormal growth and keratin changes, modeling early cancer development.

Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors by Microarray Analysis

research Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors (SKP) by Microarray Analysis

6 citations , April 2010 in “Cellular Reprogramming”

Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.

research Transgenic HPV11-E2 protein modulates URR activity in vivo

2 citations , February 2023 in “Transgenic Research”

The E2 protein affects gene activity in hair follicles of mice.

research Ber‐EP4 antigen is a marker for a cell population related to the secondary hair germ

21 citations , June 2004 in “Experimental Dermatology”

Ber‐EP4 marks cells related to the secondary hair germ in hair follicles.

research CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice

141 citations , May 2007 in “Cancer Research”

CD34 is crucial for skin tumor development in mice.

research High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders

15 citations , November 2022 in “Cell Death and Disease”

CEP135 may predict cancer outcomes, and targeting PLK1 could help treat certain sarcomas.

research Skin stem cells and tumor growth : functions of collagen XVIII in hair follicle cycling and skin cancer, and Bmx tyrosine kinase in tumor angiogenesis

3 citations , January 2014

Collagen XVIII and Bmx tyrosine kinase are important for hair growth and skin cancer development.

research The use of polyethylenimine–DNA to topically deliver hTERT to promote hair growth

17 citations , May 2011 in “Gene Therapy”

Using polyethylenimine-DNA to deliver the hTERT gene can stimulate hair growth and may be useful in treating hair loss, but there could be potential cancer risks.

research Removing all obstacles: A critical role for p53 in promoting tissue renewal

30 citations , April 2010 in “Cell Cycle”

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.

research Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma

10 citations , December 2015 in “International Journal of Dermatology”

CK 15, follistatin, and Bmi-1 can help differentiate basal cell carcinoma from squamous cell carcinoma.

research Identification and dissection of an enhancer controlling epithelial gene expression in skin

29 citations , February 2001 in “Proceedings of the National Academy of Sciences”

A specific DNA region controls skin cell gene expression by working with certain proteins.

research Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

January 2022 in “Research Square (Research Square)”

High TSPEAR levels in colorectal cancer predict worse outcomes.

research The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles

35 citations , February 2019 in “Cell Communication and Signaling”

BMP6 and Wnt10b control whether hair follicles are resting or growing.

research Epidermal and Hair Follicle Progenitor Cells Express Melanoma-Associated Chondroitin Sulfate Proteoglycan Core Protein

51 citations , February 2004 in “Journal of Investigative Dermatology”

MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.

research Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency

77 citations , January 1980 in “Carcinogenesis”

TPA is about 50 times more effective at promoting tumors than MZ.

research 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia

1 citations , November 2022 in “Journal of Investigative Dermatology”

ALRN-6924 may prevent hair loss caused by chemotherapy.

research FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation

November 2025 in “Biomolecules”

FGF22 helps hair follicle stem cells grow and develop.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations , September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Gene profile analysis of colorectal cancer cell lines by cDNA macroarray

10 citations , May 2007 in “Oncology Reports”

Colorectal cancer's ability to spread is due to changes in many genes, not just one.

Uncoupling Desmosomal Cadherin Adhesion Activates Quiescent Hair Follicle Stem Cells and Orchestrates Self-Organized Regeneration Through Outside-In Signaling

research 1422 Uncoupling desmosomal cadherin adhesion activates quiescent hair follicle stem cells and orchestrates self-organized regeneration through outside-in signaling

April 2023 in “Journal of Investigative Dermatology”

Disrupting a specific protein's function in hair follicle stem cells triggers their activation and a self-healing process.

research Transduction‐induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma‐like phenotype

5 citations , August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

research Sox9 expression in canine epithelial skin tumors

8 citations , July 2015 in “European journal of histochemistry”

Sox9 is present in most canine skin tumors and may help understand stem cells' role in these cancers.

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

VEGF promotes hair follicle cell growth through the VEGFR-2/ERK pathway.

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