FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation

    November 2025 in “ Biomolecules ”
    Yu Luo, Tong Xiao, Binpeng Xi, Yufang Song, Zengkui Lu, Chao Yuan, Jianbin Liu, Tingting Guo
    TLDR FGF22 helps hair follicle stem cells grow and develop.
    This study investigates the role of FGF22 secreted by dermal papilla cells (DPCs) in regulating hair follicle stem cell (HFSC) proliferation and differentiation. Using a DPC-HFSC co-culture system, it was found that FGF22 overexpression in DPCs significantly increased FGFR1/FGFR2 mRNA expression and HFSC viability while reducing apoptosis. Conversely, FGF22 knockout decreased FGFR1/FGFR2 expression, reduced HFSC proliferation, and increased apoptosis. FGF22 promotes HFSC proliferation and differentiation by activating Wnt/β-Catenin, Sonic Hedgehog, and Notch signaling pathways, while inhibiting BMP pathways. These findings provide insights into potential applications in regenerative medicine and hair loss treatment.
    Discuss this study in the Community →

    Research cited in this study

    19 / 19 results

    Related Community Posts Join

    6 / 7 results

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 2 years ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      by MagicBold in Research  865 upvotes 1 year ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 2 years ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Stop expecting results in 2 months!

      in Treatment  125 upvotes 1 year ago
      People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  7 upvotes 1 year ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

    Similar Research

    5 / 761 results