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Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Standard treatment for congenital erythropoietic porphyria was ineffective over five years.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

A point mutation in the androgen receptor gene causes complete androgen insensitivity.

CCCA may involve the PD1/PDL1 pathway and increased caspase 3, leading to permanent hair loss.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

A new genetic variant in the LIPH gene causes hair growth issues in a Chinese patient.

Enzyme replacement therapy may help alleviate symptoms in complex cases like this.

A mouse gene mutation increases the risk of skin cancer.

Mutations in the HEPHL1 gene cause abnormal hair and cognitive issues.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

A new gene mutation causes insulin resistance in a girl and her mother.

CYP11A1 is crucial for skin health and disease by producing important steroids.

The rs231775 genetic variant is linked to a higher risk and severity of Alopecia Areata in males.

CXCR2 in skin cells promotes tumor growth.

20(S)-Protopanaxadiol-aglycone may help prevent and treat prostate cancer by reducing androgen receptor activity.

Changes in KRT17 gene activity linked to wool production in Angora rabbits.

A KRT32 gene variant causes loose anagen hair syndrome.

Certain genetic variations in IGF2BP2 and IGFBP3 are linked to a higher risk of PCOS.

A certain gene variant may increase the risk of polycystic ovary syndrome in Chinese women.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

Finasteride shows promise for preventing prostate cancer, but more research is needed.

PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.

Testing basal 17-HP levels is a good way to screen for nonclassic adrenal hyperplasia in women with high androgen levels.

The MTHFR C677T mutation may increase the risk of alopecia areata in the Turkish population.

Increased energy use in Pik3r1-related insulin resistance isn't due to Ucp1 thermogenesis.