Search

for
Search:

Sort by

Research

870-900 / 1000+ results

research Prostate cancer incidence among finasteride and alpha-blocker users in the Finnish Prostate Cancer Screening Trial

49 citations , August 2009 in “British Journal of Cancer”

Finasteride might lower the risk of low-grade prostate cancer but not high-grade cancer, while alpha-blockers might reduce high-grade cancer risk.

research Tyrosine kinase inhibition and grey hair

59 citations , March 2003 in “The Lancet”

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.

research 705 Ablation of alkaline phosphatase in human dermal papilla spheroid impairs hair follicle induction

April 2016 in “Journal of Investigative Dermatology”

Removing alkaline phosphatase from human skin cells hinders the creation of new hair follicles.

research The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling

July 2025

Blocking CXCR4 may help treat hidradenitis suppurativa.

Spatial Transcriptomic Analysis of Imiquimod-Treated Mouse Skin Reveals Deregulation of Lipid Raft-Associated Markers Reversible by Caveolin Scaffolding Domain Peptide

research 1619 Spatial transcriptomic analysis of imiquimod-treated mouse skin reveals deregulation of lipid raft-associated markers which could be reversed by re-introduction of caveolin scaffolding domain peptide

April 2023 in “Journal of Investigative Dermatology”

The research found that a protein called caveolin-1 is reduced in psoriasis, but reintroducing it can help alleviate some psoriasis symptoms.

research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

research Study on the regulatory effect of Panax notoginseng saponins combined with bone mesenchymal stem cell transplantation on IRAK1/TRAF6-NF-κB pathway in patients with diabetic cutaneous ulcers

10 citations , January 2023 in “Journal of Orthopaedic Surgery and Research”

Panax notoginseng saponins with stem cells improve healing and reduce inflammation in diabetic ulcers.

Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocyte Differentiation in Hair Follicle

research Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle

8 citations , January 2017 in “Stem Cells International”

A protein called sFRP4 from skin cells stops the development of pigment-producing cells in hair.

research PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

38 citations , January 2017 in “PPAR Research”

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

research The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway

January 2024 in “Cells”

Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.

JAK Inhibitors in the Therapy of Comorbid Diseases: Atopic Dermatitis and Alopecia Areata - Literature Review and Clinical Practice Experience

research JAK-inhibitors in the therapy of comorbid diseases – atopic dermatitis and alopecia areata: literature review and experience of clinical practice

2 citations , March 2024 in “Meditsinskiy sovet = Medical Council”

JAK inhibitors effectively treat severe atopic dermatitis and alopecia areata.

research Pre-keratin isolated from epidermal microsomes

7 citations , December 1970 in “Biochimica et Biophysica Acta (BBA) - Protein Structure”

Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

research Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease interactions

3 citations , April 2023 in “Frontiers in Pharmacology”

ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

research 1. 2年間の低負荷レジスタンストレーニングが高齢者の筋機能に及ぼす効果(第134回日本体力医学会関東地方会)

October 2005 in “体力科學”

Blocking 5α-reductase can reduce sleep deprivation-related behavioral issues in rats.

research Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS)

March 2026 in “The Aging Male”

PDE5 inhibitors cause earlier adverse events in BPH treatment, requiring careful monitoring.

research The investigation of selective sphingosine-1 phosphate receptor 1&4 modulator to treat alopecia areata mouse model 2881

November 2025 in “The Journal of Immunology”

The S1PR 1&4 modulator may effectively treat alopecia areata by reducing hair loss and immune cell activity.

research AIMP1-derived peptide secreted from hair follicle stem cells activates dermal papilla cells to promote hair growth

1 citations , February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

A peptide from hair follicle stem cells promotes hair growth by activating specific skin cells.

research 861 EGFR/MEK inhibitor therapy induces partial hair follicle immune privilege collapse in vivo and ex vivo

July 2022 in “Journal of Investigative Dermatology”

Characterization of Response of Murine Hair Follicle-Derived Keratinocytes Against Androgen and Testosterone 5α-Reductase Activity

research Characterization of response of murine hair follicle-derived keratinocyte against androgen and testosterone 5α-redactase activity

August 1994 in “Journal of dermatological science”

Mouse hair cells respond to male hormones by growing less, and this can be stopped by certain blockers.

research Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery

November 2025 in “Journal of Medicinal Chemistry”

Topical PROTACs show promise for treating skin conditions but need better stability and delivery methods.

research Charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping

10 citations , November 2017 in “Letters in drug design & discovery”

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

research Upadacitinib in the treatment of a patient with the triad of atopic dermatitis, vitiligo, and alopecia areata: a case report and literature review

June 2026 in “Frontiers in Immunology”

This case report highlights the successful use of upadacitinib, a selective JAK1 inhibitor, in treating a 57-year-old man with severe atopic dermatitis, vitiligo, and alopecia areata, conditions that share the JAK-STAT signaling pathway. Conventional therapies had failed, but upadacitinib (15 mg daily) led to rapid improvement: pruritus subsided within days, AD-related erythema cleared by 15 weeks, complete eyebrow regrowth occurred within months, and significant vitiligo repigmentation was observed at one year. The treatment was well-tolerated, suggesting that upadacitinib monotherapy could be an effective and well-tolerated option for these co-existing conditions, supporting a "multi-disease therapy" approach targeting common pathogenic pathways.

Anti-Inflammatory Effects in LPS-Treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-San

research Anti-inflammatory Effects in LPS-treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-san

December 2021 in “Daehanhanuihakoeji”

The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.