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GlossaryParathyroid Hormone

regulates blood calcium levels by acting on bones, kidneys, and intestines

Parathyroid Hormone (PTH), also known as parathormone or parathyrin, is a hormone produced by the parathyroid glands, which are small glands located behind the thyroid in the neck. PTH plays a crucial role in regulating calcium levels in the blood by increasing calcium absorption in the intestines, releasing calcium from bones, and conserving calcium in the kidneys. This hormone is essential for maintaining bone health and proper functioning of the nervous and muscular systems.

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research The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia

15 citations , January 2015 in “Skin Pharmacology and Physiology”

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

Treatment of Alopecia Areata in Mice by Stimulating Hair Follicles Using Parathyroid Hormone Agonists Linked to a Collagen Binding Domain

research Treatment of Alopecia Areata in Mice by Stimulating the Hair Follicles Using Parathyroid Hormone Agonists Linked to a Collagen Binding Domain

January 2015 in “Journal of clinical & experimental dermatology research”

A protein combining parathyroid hormone and collagen helped hair regrow in mice with a hair loss condition.

Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition

research Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition

52 citations , May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Parathyroid hormone-related protein helps control hair growth phases in mice.

research A Topical Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Antagonist Stimulates Hair Growth in Mice

26 citations , December 2006 in “Endocrinology”

A cream with a specific hormone blocker increases hair growth in mice.

research The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation

24 citations , March 2016 in “Journal of Investigative Dermatology”

TIP39 and PTH2R help control calcium levels and skin cell development.

research Clinical uses for calciotropic hormones 1,25-dihydroxyvitamin D3 and parathyroid hormone-related peptide in dermatology: a new perspective.

23 citations , April 1996 in “PubMed”

Vitamin D3 and parathyroid hormone-related peptide may have important uses in skin treatments.

research Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

March 2025 in “FEBS Journal”

Epiprofin suppresses parathyroid hormone gene activity, helping regulate calcium levels and could be a treatment target for hyperparathyroidism.

research Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

211 citations , February 1994 in “Proceedings of the National Academy of Sciences”

Too much parathyroid hormone-related protein in skin disrupts hair growth in mice.

research Parathyroid Hormone-related Protein in Normal and Neoplastic Canine Tissues: Immunohistochemical Localization and Biochemical Extraction

54 citations , May 1994 in “Veterinary Pathology”

PTHrP is higher in certain dog tumors and may act as a local growth factor.

Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

research Parathyroid Hormone Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

33 citations , May 2006 in “Journal of Investigative Dermatology”

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

research Treatment for chemotherapy‐induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain

24 citations , December 2011 in “International Journal of Cancer”

PTH-CBD agonists may help regrow hair after chemotherapy.

research A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone–Collagen Binding Domain (PTH–CBD), Results in Sustained Increases in Bone Mineral Density for up to 12 Months in Normal Female Mice

23 citations , July 2012 in “Calcified Tissue International”

A single injection of PTH–CBD can increase bone density for up to a year.

Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

research Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model

20 citations , September 2013 in “Anti-Cancer Drugs”

PTH-CBD could help prevent and treat hair loss caused by chemotherapy in mice.

research Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain

12 citations , November 2015 in “Journal of Investigative Dermatology Symposium Proceedings”

PTH-CBD helps reduce hair loss in mice by stimulating hair growth directly.

research Parathyroid hormone-related peptide and the hair cycle - is it the agonists or the antagonists that cause hair growth?

9 citations , July 2014 in “Experimental Dermatology”

PTHRP agonists can stimulate hair growth, especially in damaged follicles, while antagonists may initially increase growth but ultimately inhibit it.

Parathyroid Hormone Linked to a Collagen Binding Domain Promotes Hair Growth in a Mouse Model of Chemotherapy-Induced Alopecia in a Dose-Dependent Manner

research Parathyroid hormone linked to a collagen binding domain promotes hair growth in a mouse model of chemotherapy-induced alopecia in a dose-dependent manner

8 citations , April 2014 in “Anti-Cancer Drugs”

A hormone linked to collagen helps hair grow back in mice after chemotherapy, and may also prevent bone loss.

research The parathyroid hormone-related protein as a regulator of normal tissue functions

4 citations , January 1994 in “Current Opinion in Endocrinology & Diabetes”

PTHrP regulates various normal body functions, including bone development, skin, and muscle function.

research Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

478 citations , September 1996 in “Proceedings of the National Academy of Sciences”

Overexpression of PTHrP in chondrocytes causes short-limbed dwarfism and delayed bone formation in mice.

research The role of vitamin D deficiency in parathyroid hormone levels

10 citations , January 2013 in “TURKISH JOURNAL OF MEDICAL SCIENCES”

Low vitamin D levels can lead to increased parathyroid hormone levels.

research Therapy for Alopecia Areata in Mice Using Parathyroid Hormone Agonists and Antagonists, Linked to a Collagen-Binding Domain

4 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

research Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies

15 citations , June 2020 in “Experimental Dermatology”

Hormones and genes affect hair growth and male baldness.

research The human skin as a hormone target and an endocrine gland

146 citations , January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

research The clinical spectrum of parathyroid disease

8 citations , December 1981 in “Journal of The American Academy of Dermatology”

The document concludes that parathyroid diseases have a range of clinical features and outcomes, with some conditions being treatable and others having a high risk of mortality.

research Parathyroid adenoma with coeliac disease: primary or quaternary hyperparathyroidism? Gruczolak przytarczyc i choroba trzewna: pierwotna czy czwartorzędowa nadczynność przytarczyc?

January 2012

A gluten-free diet and removing the parathyroid adenoma helped a girl with coeliac disease and high calcium levels start puberty.

The 'Bald' Phenotype (Androgenetic Alopecia) Is Caused by the High Glycemic, High Cholesterol, and Low Mineral 'Western Diet'

research The ‘bald’ phenotype (androgenetic alopecia) is caused by the high glycaemic, high cholesterol and low mineral ‘western diet’

7 citations , June 2021 in “Trends in Food Science and Technology”

Western diet may cause male pattern baldness; low glycemic diet with magnesium could help.

research Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract

3 citations , January 2021 in “FEBS open bio”

Camellia japonica extract may improve scalp health and promote hair growth.

research VITAMIN D RESISTANT RICKETS WITH ALOPECIA: A FORM OF END ORGAN RESISTANCE TO 1,25 DIHYDROXY VITAMIN D

82 citations , April 1981 in “Clinical endocrinology”

A girl with rickets and hair loss was found to have a rare condition where her body didn't respond to vitamin D treatment.

research The impact of VDR expression and regulation in vivo

25 citations , June 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

VDR regulation varies by tissue and is crucial for its biological functions.

research Menopause

3 citations , January 2007 in “Elsevier eBooks”

The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.

research Pharmacological Treatment of Alopecia

1 citations , October 2018 in “InTech eBooks”

Only minoxidil and finasteride are FDA-approved for hair loss, with other treatments available but less effective or with side effects.