research Convergent Decay of Skin-specific Gene Modules in Pangolins
Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.
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research Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program
Ritlecitinib is safe and well-tolerated for treating alopecia areata in patients aged 12 and older.
research Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies
New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
research Hair follicles and their role in skin health
Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.
research Tapinarof cream for atopic dermatitis: Pharmacokinetics, systemic exposure, and preliminary efficacy/safety results
Tapinarof cream at 1% concentration is effective and better tolerated for treating atopic dermatitis than the 2% concentration.
research Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer
Certain genetic variants increase the risk of aggressive prostate cancer.
research 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia
Genetic changes in specific proteins contribute to hair loss in some women of African descent.
research Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review
Oral dutasteride works better for hair loss, but has more sexual side effects; intralesional dutasteride is a possible alternative.
research Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies
Tyrosine kinase inhibitors for endocrine tumors often cause skin issues, requiring early management and treatment adjustments.
research Alopecia and Clinical Presentation of Endocrinopathies: Pathogenetic and Diagnostic Aspects
Hormonal imbalances can cause hair loss, and understanding them can help develop better treatments.
research Distinct Phenotypic and Genomic Signatures Underlie Contrasting Pathogenic Potential of Staphylococcus epidermidis Clonal Lineages
Staphylococcus epidermidis A/C strains are more antibiotic-resistant and infection-adapted, while B strains thrive in hair follicles.
research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
research Evaluating the Metabolomic Profile and Anti-Pathogenic Properties of Cannabis Species
Cannabis has anti-inflammatory and antimicrobial properties, but more research is needed on its effects on plant and aquatic animal pathogens.
research Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events
Nanotechnology can improve wound healing by enhancing treatments and dressings.
research Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia
Low testosterone may indicate severe COVID-19 in men.
research Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study
Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.
research Industrial-scale processing of activated platelet-rich plasma from specific pathogen-free pigs and its effect on promoting human hair follicle dermal papilla cell cultivation
Pig blood plasma can be used to promote human hair growth and is a good alternative to the commonly used serum additive.
research Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) in the majority of the alopecia areata patients: Is it a primitive and pathogenic perturbation of hypothalamic-pituitary-adrenal axis?
Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.
research Cytokine-Targeting Biologic Therapies for Alopecia Areata: A Comprehensive Review of Mechanism of Action, Clinical Efficacy, and Adverse Events
Dupilumab and ustekinumab are promising treatments for alopecia areata, showing significant hair regrowth.
research Hormonal interventions in skin wounds – a mini review
Hormones can improve wound healing by regulating the healing process.
research SYK inhibitor entospletinib prevents ocular and skin GVHD in mice
Entospletinib effectively prevents eye and skin GVHD in mice.
research Third International Research Workshop on Alopecia Areata
Alopecia areata is complex, with genetic and immune factors, and animal models are key for future treatment research.
research Challenges associated with the identification of germline variants on myeloid malignancy genomic profiling—a Singaporean experience
Genomic profiling for myeloid cancers can find important inherited mutations, but it's challenging when these mutations aren't related to the patient's symptoms.
research Neurobiology, Stem Cell Biology, and Immunology: An Emerging Triad for Understanding Tissue Homeostasis and Repair
The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.
research Platelet-rich plasma therapy: key infection prevention practices and strategies for safety risk reduction
Standardized protocols are crucial for safe and infection-free platelet-rich plasma therapy.
research Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Cellular and immunotherapies show promise for healing chronic wounds but need more research.
research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
research Grand challenges in dermatologic drug discovery: four priorities to transform skin disease treatment
Transforming skin disease treatment requires new strategies, better drug models, and patient-focused research.
research 307 Dermatologic toxicities associated with chronic gamma-secretase inhibitor treatment for desmoid tumor
Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.
research Comprehensive Program Planning for the Integration of 21st Century Learning Center After-School Programs with Regular Day Programs and Community Partners.
The report expanded knowledge of MBTPS1-related disorders by identifying new symptoms.