research Evolution, classification, structure, and functional diversification of steroid 5α-reductase family in eukaryotes
Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.
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840-870 / 1000+ resultsresearch Smooth muscle cell expression of a constitutive active form of human Profilin1 accelerates cutaneous wound repair
Profilin1 speeds up wound healing.
research Polydeoxyribonucleotides – the future of regenerative medicine
Polydeoxyribonucleotides may help with healing and anti-aging, but more research is needed.
research Connexin 43 expression in the testes during postnatal development of finasteride-treated male rat offspring
Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.
research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein
The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.
research 876 Imaging nanoscale changes in desmosome protein organization
Desmoglein 3 organization in cell connections changes without calcium, affecting cell adhesion.
research Finasteride: not guilty after all?
Finasteride reduces prostate cancer risk but may increase aggressive cancer risk slightly.
research Adverse effects of the 5-alpha-reductase inhibitor finasteride on Daphnia magna: Endocrine system and lipid metabolism disruption
Finasteride harms Daphnia magna's reproduction, growth, and metabolism.
research The Benefits of Dual Inhibition of 5α Reductase
Dutasteride reduces DHT and improves BPH symptoms more effectively than finasteride.
research Effects of Oral Finasteride on Erectile Function in a Rat Model
Finasteride reduces corpus cavernosum weight but doesn't affect erectile response in rats.
research The role of phosphoglycerate dehydrogenase in cell proliferation and tumor progression
PHGDH promotes cancer growth by aiding cell proliferation and tumor progression.
research 5 알파환원효소억제제 (Finasteride)가 경요도전립선절제술 중의 출혈에 미치는 영향
research Anabolic effects of testosterone are preserved during inhibition of 5α-reductase
Testosterone can build muscle and bone without enlarging the prostate when a specific enzyme is blocked.
research GBP1 as a machine learning-prioritized biomarker and therapeutic target for epstein-barr virus-induced clear cell renal cell carcinoma: multi-omics causal validation
GBP1 is a key target for treating Epstein-Barr virus-related kidney cancer, and finasteride may help.
research An effective range of polydeoxyribonucleotides is critical for wound healing quality
Classic PDRN improves wound healing quality by enhancing cell migration.
research 5alpha-reductase 2 inhibition impairs brain defeminization of male rats: Reproductive aspects
5alpha-reductase 2 is crucial for proper male brain development and sexual differentiation.
research (379) The Effect of 5-α Reductase Inhibitor on Male Reproductive Function
5-α reductase inhibitors do not significantly affect male reproductive function but may reduce semen volume.
research Post-finasteride syndrome: a surmountable challenge for clinicians
Finasteride can cause serious side effects in some men, needing more research for treatment.
research Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation
Peptide drugs now target hard-to-reach proteins more effectively and specifically.
research Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase
Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.
research MP13-07 FINASTERIDE MONOTHERAPY BEFORE TURP: SIGNIFICANT IMPROVEMENT IN EARLY POSTOPERATIVE QUALITY OF LIFE
Finasteride before TURP reduces blood loss and improves early postoperative quality of life.
research Major role for 5-alpha reductase inhibitors in the aging male
5-alpha reductase inhibitors help treat prostate issues in aging men, but their role in cancer prevention is debated.
research Inappropriate Sexual Behaviors in Patients with Vascular Dementia: Possible Response to Finasteride
Finasteride may help reduce inappropriate sexual behaviors in dementia patients with prostate issues.
research Antipsychotic-Like Properties of 5-α-Reductase Inhibitors
research Ejaculations and Benign Prostatic Hyperplasia: An Impossible Compromise? A Comprehensive Review
Men with BPH should discuss potential sexual side effects with doctors before treatment, as some treatments can affect ejaculation.
research Influence of age and of testosterone on the response of male rats to parachlorophenylalanine
PCPA induces hypersexual behavior in male rats regardless of age or castration status.
research Non-Edg family LPA receptors: the cutting edge of LPA research
New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.
research Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin
Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.
research Effects of finasteride on expression of vascular endothelial growth factor and microvascular density in retina of early diabetic rats
Finasteride reduces VEGF expression and microvascular growth in diabetic rat retinas.
research RE: EFFECT OF THE DUAL 5α-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCER
Dutasteride may help shrink prostate cancer tumors.