2 citations
,
April 2014 in “PubMed” Epidermal neural crest stem cells from hair follicles can help repair nerve injuries.
3 citations
,
May 2019 in “Journal of Cosmetic Dermatology” Pro-Ile could be used in cosmetics to improve skin, hair growth, and healing.
January 2000 in “Neuroscience Research” January 2026 in “International Journal of Molecular Sciences” Topical peptides may offer safer, effective pain relief and healing for wounds.
September 2004 in “Experimental Dermatology” The model effectively studies how sensory nerves interact with skin components, aiding research on wound healing and hair growth.
13 citations
,
December 2009 in “Journal of the Peripheral Nervous System” TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.
36 citations
,
September 2009 in “Molecular Neurobiology” April 2026 in “Frontiers in Cell and Developmental Biology” G-protein-coupled receptors (GPCRs) are crucial in the wound healing process, influencing immune cell recruitment and signaling pathways like Hedgehog-GLI, Hippo-YAP1, and Wnt/β-catenin, which are involved in epidermal cell proliferation and differentiation. By modifying GPCR activity with agonists or antagonists, it is possible to impact immune cell infiltration, inflammatory mediator production, and the rate of wound healing. This review discusses the fundamental mechanisms of GPCR signaling in wound healing and recent discoveries about their roles and functions.
September 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Special gut cells help stem cells move to and fix injured areas by activating a specific signaling pathway.
10 citations
,
January 2014 in “BioMed research international” Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.
1 citations
,
June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” The symposium highlighted the skin's role in sensing itch, pain, touch, and pleasure, and discussed new research and techniques for understanding and treating these sensations.
January 2026 in “Clinical Cosmetic and Investigational Dermatology” Placenta polypeptide injection is a safe and effective treatment for sensitive skin.
April 2017 in “Journal of Investigative Dermatology” Cholecystokinin may help reduce skin inflammation in psoriasis.
9 citations
,
October 1994 in “Brain Research” Fetal sheep develop skin nerve pathways and responses to touch and heat between 75 and 134 days of gestation.
228 citations
,
September 2012 in “Trends in Neurosciences” Nerves are crucial for the regeneration of various body parts in many animals.
April 2021 in “Journal of Investigative Dermatology” Bacteria can help skin regenerate through a process called IL-1β signaling.
3 citations
,
January 2005 in “Biological & Pharmaceutical Bulletin” The peptide GPIGS helps hair cells grow and speeds up hair regrowth in mice.
15 citations
,
May 2003 in “The Laryngoscope” FGF-1 causes spiral ganglion neurites to branch more.
January 1981 in “Purdue e-Pubs (Purdue University)” Pig skin is similar to human skin, with no major changes as they age.
8 citations
,
January 2022 in “Current topics in developmental biology/Current Topics in Developmental Biology”
6 citations
,
September 2021 in “Experimental Brain Research” Rats have different touch receptors in their paws that help with movement and handling objects.
105 citations
,
August 2010 in “Pharmacology & therapeutics” Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
24 citations
,
March 2016 in “Journal of Investigative Dermatology” TIP39 and PTH2R help control calcium levels and skin cell development.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The back of the scalp has more nerve fibers than the front, which may explain why some people feel more sensitivity there.
1 citations
,
July 2016 in “Livestock science” Nerve growth factor helps cashmere goat hair cells grow and is more active during the hair growth phase.
67 citations
,
January 1992 in “Journal of Investigative Dermatology”
24 citations
,
April 2013 in “PLOS ONE” TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.
September 2024 in “Journal of the American Academy of Dermatology” Oxytocin receptors are found in skin cells near touch and pain neurons.
January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The gp130 receptor helps in tissue regeneration and disease progression, and manipulating it could improve healing and prevent disease.
1 citations
,
June 2015 in “Journal of anatomy” A compound named ZCZ90 can increase muscle spindle firing, potentially helping treat muscle spasms and hypertension.