949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
425 citations
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June 2020 in “Nature” Scientists created human skin with hair from stem cells, which could help treat hair loss and skin conditions.
198 citations
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March 1999 in “Journal of Investigative Dermatology” Keratin 15 helps maintain tissue integrity and is reduced in activated keratinocytes.
105 citations
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October 2017 in “Stem cells” Wnt signaling is crucial for skin development and hair growth.
100 citations
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December 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
79 citations
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January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology” Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.
73 citations
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January 2002 in “Journal of Investigative Dermatology” Epidermal stem cells don't use gap junctions to communicate.
72 citations
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November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
60 citations
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December 2003 in “Journal of Investigative Dermatology” K6hf is found in specific parts of hair follicles, nails, and tongue, and is linked to hair growth and structure.
53 citations
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October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Topical calcitriol-analogs can reduce hair loss caused by chemotherapy.
52 citations
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October 2007 in “Molecular Therapy” Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.
46 citations
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May 2003 in “Mechanisms of Development” Increasing calcium sensing receptor speeds up skin and hair development in mice.
39 citations
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September 2007 in “BMC developmental biology” Neuregulin3 affects cell development in the skin and mammary glands.
31 citations
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April 2004 in “Journal of Investigative Dermatology” A new mouse gene, Keratin 17n, is mainly found in nail tissue and may explain why mice without Keratin 17 don't have nail issues.
31 citations
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September 2012 in “Journal of biological chemistry/The Journal of biological chemistry” The right amount of retinoic acid is essential for normal hair growth and development.
28 citations
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September 1998 in “Journal of Investigative Dermatology” Two distinct caspases in human skin help with cell death and skin formation.
20 citations
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November 2014 in “Developmental Dynamics” Palate formation and skin healing share similar biological processes.
20 citations
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February 2010 in “Journal of Investigative Dermatology” Slug (Snai2) helps regulate hair growth timing in mice.
18 citations
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March 2023 in “Molecular Therapy — Nucleic Acids” Mechanical stimuli and CCL2 can help regenerate hair follicles in adult mice.
15 citations
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July 2024 in “Current Issues in Molecular Biology” Understanding molecular processes in skin development is key to creating targeted treatments for skin disorders.
14 citations
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June 2022 in “BMC genomics” Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.
12 citations
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March 2022 in “Development” Mechanical forces are crucial in shaping our sensory organs during development.
5 citations
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June 2022 in “Biophysical Journal” TGF-β and TNF influence hair follicle cell fate, with TNF being more effective in triggering cell death.
5 citations
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November 2003 in “Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic” The exact causes of baldness are not fully understood, limiting treatment options.
2 citations
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November 2023 in “Biomolecules” WNT signaling is crucial for skin development and healing.
2 citations
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June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Epigenetic factors play a crucial role in skin health and disease.
1 citations
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September 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin organoids from stem cells can help study and treat skin issues but face some challenges.
1 citations
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August 2022 in “Molecules” Prunus mira kernels contain components that can promote hair growth in mice.
March 2026 in “Cell Death Discovery” Targeting the p63 gene could help treat skin diseases.
March 2026 in “Frontiers in Cell and Developmental Biology” Understanding how certain proteins and genetic changes control skin stem cells is key to treating skin diseases.