69 citations
,
January 2002 in “Journal of biomedical optics” Dyes can penetrate human skin and hair follicles up to 1.2 mm deep and the sebaceous gland can store dye; Indocyanine Green lotion was made for safe dyeing and monitoring.
July 2022 in “Journal of Investigative Dermatology” The combination of a plant extract and a peptide can increase hair pigmentation and may reverse greying.
9 citations
,
May 2019 in “Vestnik dermatologii i venerologii” The method could improve vitiligo treatment by effectively delivering therapy to hair follicles.
60 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Applying a specific inhibitor lightens skin and hair color.
November 2024 in “Jurnal Biomedika dan Kesehatan” Premature graying in young children can affect self-esteem, and addressing underlying health issues may reverse it.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” Natural hair dyes using plants like henna and indigo are safer and eco-friendly alternatives to synthetic dyes.
20 citations
,
August 1981 in “Developmental Medicine & Child Neurology” 13 citations
,
June 1981 in “Developmental Medicine & Child Neurology”
12 citations
,
June 2010 in “Journal of dermatology” Some patients with severe alopecia areata developed skin darkening from their treatment, which may indicate a less effective response to the therapy.
3 citations
,
May 2020 in “Acta pharmaceutica” Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.
28 citations
,
December 2019 in “Skin appendage disorders” Some medications might reverse gray hair, especially those that reduce inflammation or stimulate pigment production, and vitamin B might help.
13 citations
,
March 2010 in “International Journal of Cosmetic Science” Hair coloring increases copper and calcium uptake, damaging hair and reducing shine.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” Henna is a safer, natural hair dye but needs more research and standardization.
20 citations
,
October 2018 in “American Journal of Clinical Dermatology” Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.
May 2024 in “Pigment International” Several treatments are effective for pigmentary disorders like vitiligo and melasma.
31 citations
,
October 1992 in “Journal of Clinical Pharmacy and Therapeutics” Some medications can change hair color, especially chloroquine and cancer treatments.
2 citations
,
May 2023 in “Photobiomodulation, photomedicine, and laser surgery” Light therapy is effective and safe for treating skin color disorders like vitiligo and dark spots.
7 citations
,
September 2021 in “Journal of Applied Polymer Science” Cuttlefish ink melanin protects hair from UV damage.
November 2017 in “Koubunshi rombunshuu/Kōbunshi ronbunshū” Hematin in shampoo helps repair and straighten damaged hair.
4 citations
,
December 2018 in “Macedonian Journal of Chemistry and Chemical Engineering” A new method accurately measures amino acids in treated hair, showing bleaching reduces amino acids while protein treatments increase them.
November 2024 in “Majalah Farmasetika” The natural hair dye gel with 12% Eleutherine bulbosa extract effectively colors bleached hair dark brown and is stable and non-irritating.
November 2025 in “Journal of Cosmetic Dermatology” Exosome therapy can safely and effectively restore color to gray hair.
April 1986 in “CRC Press eBooks” Hair color is determined by melanins produced in hair cells.
March 1942 in “The Science News-Letter” 5 citations
,
November 2003 in “PubMed” Chemical treatments and light exposure damage hair proteins.
9 citations
,
November 2015 in “JAMA dermatology” A 91-year-old woman's hair turned black in one spot, with skin changes underneath.
September 2019 in “Journal of Investigative Dermatology” PCE-DP brightens skin and promotes hair growth by enhancing cell growth and reducing melanin uptake.
1 citations
,
January 2002 in “Springer eBooks” 6 citations
,
January 2016 in “Indian Journal of Dermatology Venereology and Leprology” Most hair dyes can cause allergic reactions, so test before use.
July 1996 in “Hair transplant forum international” Using tretinoin and hydroquinone can speed up the fading of skin pigmentation.