December 2021 in “Figshare” The study explored the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis, particularly under occlusal hypofunction conditions. Researchers used RNA sequencing on 34 human teeth and found that BBS7 expression was downregulated in hypofunctional PDL, which correlated with changes in cell number, collagen fiber alignment, blood vessel diameter, and primary cilia appearance. The study highlighted that Sonic hedgehog (Shh) signaling, important for tissue regeneration, was linked to BBS7 expression. BBS7 knockdown suppressed cell migration and angiogenesis in vitro, indicating its essential role in PDL homeostasis through Shh signaling. However, the specific link between BBS family genes and occlusal force remained unclear.
May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.
April 2018 in “Journal of Investigative Dermatology” A new treatment using AGED to modulate PPAR-γ shows promise for treating scarring hair loss by protecting and repairing hair follicle cells.
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September 2013 in “Psychoneuroendocrinology” Blocking CYP17A1 enzyme may help improve certain brain function issues related to dopamine.
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July 2023 in “Clinical Pharmacology & Therapeutics” Targeted protein degraders show promise in treating cancer but need to target more diverse proteins.
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July 2020 in “Biochemical and Biophysical Research Communications” A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.
June 2026 in “Precision medicine and engineering.” The hydrogel dressing RD@PVA helps heal diabetic wounds by reducing stress and improving blood vessel growth.
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March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.
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September 2013 in “Journal of Investigative Dermatology” Hair follicle cells help protect against immune attacks by regulating T-cell activity.
Lhx2 is essential for effective Sonic Hedgehog signaling in early retinal development.
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November 2022 in “Acta Pharmaceutica Sinica B” The injectable hydrogel effectively speeds up chronic wound healing.
June 2024 in “Archives of Dermatological Research” SFRP2 and PTGDS may be key factors in female hair loss.
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September 2024 in “Biomolecules and Biomedicine” Total glucosides of paeony may help treat alopecia areata by reducing inflammation and hair loss.
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January 2022 in “BMC Genomic Data” The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.
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June 2010 in “Journal of Investigative Dermatology” New cells are added to the hair's dermal papilla during the active growth phase.
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November 2006 in “European Journal of Neuroscience” Progesterone protects rat brain cells by enhancing GABA A receptor activity.
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November 2019 in “FEBS open bio” Combining specific inducers helps dermal papilla cells regain hair-forming ability.
May 2000 in “Journal of Investigative Dermatology” Hedgehog signaling is crucial for hair development, cadherins affect cell adhesion, neutrophils play a role in skin lesions, and BP230 autoantibodies impact skin stability.
December 2021 in “Figshare” The study explored the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis, particularly under conditions of occlusal hypofunction. RNA sequencing of 34 human teeth showed that BBS7 expression was downregulated in hypofunctional PDL, resulting in atrophic changes such as reduced PDL cell numbers, altered collagen fiber alignment, and decreased blood vessel diameter. The research highlighted that Sonic hedgehog (Shh) signaling activity was closely linked to BBS7 expression, and BBS7 knockdown suppressed cell migration and angiogenesis in vitro. The findings suggested that BBS7 was essential for maintaining Shh signaling and PDL homeostasis, although the specific link between BBS family genes and occlusal force was not fully understood.
April 2018 in “The Journal of Urology” Phosphodiesterase inhibitors like tadalafil can reduce cell growth in BPH caused by CD8+ T cells in low androgen conditions.
January 2026 in “Applied Sciences” Cyclic ADP-ribose helps regulate calcium and signals that promote hair growth in hair follicle cells.
January 2026 in “British Journal of Dermatology” Caffeine and DMG increase calcium influx in hair follicle cells without being toxic.
104 citations
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May 2003 in “Endocrinology” Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.
Researchers created a new mouse model, G4, that mimics human PCOS symptoms and links the condition to a specific gene.
May 2005 in “Molecular Carcinogenesis” mrp/plf-mRNA can indicate tumor-promoting effects in skin.
December 2021 in “Figshare” The study explored the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis, particularly under occlusal hypofunction conditions. Researchers used RNA sequencing on 34 human teeth and found that BBS7 expression was downregulated in hypofunctional PDL, leading to changes in cell number, collagen fiber alignment, blood vessel diameter, and primary cilia appearance. BBS7 was shown to be crucial for Sonic hedgehog (Shh) signaling activity, which is important for PDL homeostasis. Knockdown of BBS7 resulted in suppressed cell migration and angiogenesis in vitro, underscoring its role in periodontal health. However, the specific association of each BBS family gene with occlusal force was not clearly understood.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.
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November 2022 in “Frontiers in endocrinology” The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
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May 2004 in “American journal of ophthalmology” Using topical prostaglandin F2α for glaucoma may cause loss of eyelash or eyebrow pigment.
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September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic” CD2 might be a new treatment target for patchy alopecia areata.