research Androgen antagonists in androgen target tissues
Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.
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research Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor
New hybrid compound found to effectively prevent hair loss.
research Pectin Nanoparticle-Loaded Soft Coral Nephthea sp. Extract as In Situ Gel Enhances Chronic Wound Healing: In Vitro, In Vivo, and In Silico Studies
The gel with coral extract and pectin nanoparticles helps heal chronic wounds.
research Role of skin enzymes in metabolism of topical drugs
Skin enzymes convert topical drugs into active forms, affecting drug effectiveness and safety.
research Exploring the therapeutic potential of naturally occurring taxifolin, a dietary flavonoid: an updated comprehensive review
Taxifolin, found in onions and milk thistle, has health benefits but needs more research for safe use.
research Dutasteride Topical Gel Containing Herbal Extract for Male Pattern Baldness
A gel with dutasteride and 10% garlic extract may effectively treat male pattern baldness.
research Clinical Toxicityof Retinoids
Retinoids can cause skin issues and hair loss due to their effects on cell membranes.
research เภสัชจลนศาสตร์ของตำรับยาทาผิวหนัง finasteride ในหนูแรท
Topical finasteride accumulates in the skin with minimal absorption into the bloodstream.
research Indole-based derivatives effect on rats with polycystic ovary syndrome
Indole-based compounds improved ovarian health in rats with PCOS, with L-Tryptophan and Tryptophol being most effective.
research Metabolite identification by mass spectrometry of the 5α-reductase inhibitor finasteride in vitro and in vivo
Finasteride's metabolites were identified, helping understand how the drug is processed in the body.
research Study on Human Bioequivalency of Two Preparations of Finasteride
The two finasteride preparations are bioequivalent.
research Epidemiology, Diagnosis, and Treatment of Atopic Dermatitis in the Developing Countries of Asia, Africa, Latin America, and the Middle East: A Review
Atopic dermatitis is common in developing countries, but many patients receive poor care due to inconsistent guidelines and lack of resources.
research An open-access data set of pig skin anatomy and physiology for modelling purposes
The data set helps improve predictions of how substances are absorbed through pig skin.
research Studies on the Disposition of Finasteride. (I). Absorption, Distribution and Excretion of (14C)finasteride after Single Oral or Intravenous Administration in Rats.
Finasteride has different absorption and metabolism in male and female rats, with higher concentrations in certain organs and mostly excreted through feces.
research O impacto da COVID-19 no ciclo menstrual: uma perspectiva geral
The combination tablet of finasteride and doxazosin works the same as taking each drug separately.
research Tether-induced tenosynovitis: The importance of an intact skin barrier
An intact skin barrier is crucial to prevent infection in cases of tether-induced tenosynovitis.
research 267 Single- and multiple-ascending dose studies of DS-2325a, a KLK5 inhibitor for the treatment of Netherton syndrome
DS-2325a is safe and well-tolerated, supporting further development for Netherton Syndrome treatment.
research Determination of Oxymatrine in Human Plasma by HPLC-MS
A method was created to measure oxymatrine in human blood.
research Study on Plasma Concentration and Bioavailability of Wogonin in Beagle's Dogs
Improving wogonin's solubility greatly increases its absorption in the body.
research The pharmacology of methotrexate
Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
research Recent advances in drug repositioning and rediscovery for different therapeutic activities utilizing updated technological approaches
Using existing drugs for new treatments is cost-effective and safer.
research Redefining Drug Discovery: A Review of Drug Repurposing –Approaches, Benefits and Breakthroughs
Drug repurposing finds new uses for existing drugs, speeding up treatment availability and reducing costs.
research Safety profile of CAP7.1 obtained during Phase I Trial in adult patients with refractory malignancies
CAP7.1 is generally safe at 200 mg/m²/day, but can cause fatigue, nausea, hair loss, fever, and blood-related issues.
research Development of PEGylated Liposomes
PEGylated liposomal doxorubicin improves cancer treatment effectiveness and reduces side effects like heart damage and hair loss.
research Methotrexate in dermatology
Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.
research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications
PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.
research Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite
Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.
research LB1056 Phase 1b: Translational evaluation of VYN201, a pan-BD BET inhibitor, for the treatment of non-segmental vitiligo
VYN201 shows promise as a safe and effective treatment for non-segmental vitiligo.
research Meet Our Editor
Dr. Jia-You Fang is a highly experienced researcher in drug delivery and related fields, with numerous publications and international collaborations.
research Identification of hydroxylated and glucuronidated metabolites of finasteride in human bile and urine
Finasteride is extensively metabolized in the body, affecting its effectiveness and safety.