September 2017 in “Journal of Investigative Dermatology” Photodynamic therapy can potentially remove nonpigmented hair by damaging hair follicles.
15 citations
,
March 2015 in “Experimental Dermatology” Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
29 citations
,
April 1997 in “Developmental Dynamics” Trypsin slows hair growth and affects color by causing cell death in hair follicles.
1 citations
,
March 2019 in “Chinese Medical Journal” Researchers identified potential markers for human hair color stem cells.
1 citations
,
December 2024 in “Case Reports in Dermatology” Cyclophosphamide likely causes skin darkening by affecting hair follicles.
51 citations
,
August 2013 in “Journal of Investigative Dermatology” Human skin cells can create new hair follicles when transplanted into mice.
2 citations
,
March 2023 in “JAAD case reports” Hair repigmentation can indicate malignancy and should be investigated.
18 citations
,
August 2021 in “PLoS ONE” Melanocyte progenitor cells are found in human fat tissue and can become mature melanocytes, which may help treat skin issues.
3 citations
,
November 2022 in “Experimental dermatology” Melatonin may inhibit melanoma growth and has potential as a cancer therapy aid, but its effects on human skin pigmentation need more research.
2 citations
,
April 2024 in “Cosmetics” Plant extracts can help remove permanent makeup without lasers.
March 2026 in “Indian Dermatology Online Journal” Hair dye ingredient PPD can cause severe allergic reactions, including facial swelling.
105 citations
,
April 2005 in “Cell” Hair graying happens because certain cells aren't maintained properly.
Adenophora Radix extract can promote hair growth and increase melanin in mice.
6 citations
,
April 2014 in “PubMed” A man got brown patches on his skin (melasma) after taking finasteride, a hair loss treatment.
May 2019 in “CINECA IRIS Institutial Research Information System (University of Genoa)” MITF+ melanoma patients are more likely to have multiple melanomas and unique skin patterns.
March 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Fat tissue around hair follicles releases a growth factor that helps hair grow and develop color.
August 2024 in “Animal Bioscience” Exosomal miR-222-3p reduces melanin production in rabbits by targeting the SOX10 gene.
Melanin-rich skin has unique challenges in diagnosing and treating skin diseases.
58 citations
,
February 2016 in “Scientific reports” Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.
10 citations
,
May 2023 in “iScience” Sox9 is crucial for hair follicle stem cells to become melanocytes instead of glial cells.
25 citations
,
September 2006 in “Birth Defects Research” Different processes create patterns in skin and things like hair and feathers.
8 citations
,
March 2019 in “Journal of Biomedical Materials Research Part A” Sulfated hyaluronan in collagen helps hair follicle cells grow and develop better for skin grafts.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.
14 citations
,
January 1988 August 2024 in “Clinical & experimental pathology” Forensic DNA phenotyping can now predict more physical traits and ancestry from DNA, but further improvements are needed.
152 citations
,
December 2003 in “Micron” As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
27 citations
,
January 1995 Melanin in black hair protects it from sun damage better than light-brown hair.
4 citations
,
November 2020 in “Case reports in dermatology” A rare skin condition causes red, dark, bumpy facial lesions.
7 citations
,
October 2011 in “BMC Cancer” Overexpression of HDGF in melanocytes does not cause cancer.
9 citations
,
August 2005 in “Experimental Dermatology” Modified pep7, named EPM peptide, effectively promotes hair growth at low concentrations and works well with minoxidil.