Search

for
Search:

Did you mean Phosphoinositide 3-kinase?

GlossaryPhosphoinositide 3-kinase

enzyme involved in cell growth and survival signaling

Phosphoinositide 3-kinase (PI3K) is an enzyme that plays a crucial role in cell growth, proliferation, and survival by activating signaling pathways inside cells. It is particularly important in the context of cancer research, as abnormal PI3K activity can lead to uncontrolled cell division and tumor growth.

Related Terms

Sort by

Research

30 / 494 results

Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

research Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

11 citations , September 2019 in “Dermatologic Surgery”

A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Proteomic Analysis of Fetal Skin by iTRAQ Reveals Molecular Signals Underlying Inner Mongolia Cashmere Goat Hair Follicle Initiation

research Proteomic analysis of fetal skin by iTRAQ reveals molecular signals underlying Inner Mongolia Cashmere goat hair follicle initiation

1 citations , February 2023 in “All Life”

The research identified proteins that change as goat hair follicles begin to form, helping to understand how cashmere grows.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits

April 2020

Ocu-miR-205 affects hair density in Rex rabbits by influencing cell processes and signaling pathways.

research Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment

7 citations , December 2019 in “Experimental and Therapeutic Medicine”

WNT10B affects hair growth by altering gene activity in hair cells.

research Exploring the mechanism of Notopterygii rhizoma et radix in the treatment of psoriasis using a network Pharmacology approach and experimental validation

November 2025 in “Scientific Reports”

Notopterygii rhizoma et radix (Qiang Huo) can effectively treat psoriasis by reducing skin symptoms and inflammation.

research Phosphatidylinositol 3-Kinase/Akt-Dependent and -Independent Protection Against Apoptosis in Normal Human Melanocytes

16 citations , October 2004 in “Journal of Investigative Dermatology”

Normal human melanocytes can avoid cell death through multiple pathways.

research Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis

8 citations , July 2024 in “Journal of Advanced Research”

CDK inhibitors may help treat ARDS and psoriasis but need more testing for safety and effectiveness.

research Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways

73 citations , November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation

13 citations , June 2014 in “Molecular therapy”

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

Tumor Heterogeneity of Prostate Cancer and SARS-CoV2 Infection: A Complex Relationship Involving Extracellular Vesicles and the Androgen Receptor

research Hétérogénéité tumorale du cancer de la prostate et infection par le SARS-CoV2 : une relation complexe impliquant les vésicules extracellulaires et le récepteur des androgènes

June 2023 in “SPIRE - Sciences Po Institutional REpository”

Extracellular vesicles and androgen receptors may help identify prostate cancer resistance and reduce SARS-CoV-2 infection.

research Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos

7 citations , September 2019 in “Journal of Cellular Physiology”

Akt2 protein is essential for normal cell division in early mouse embryos.

The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis

9 citations , April 2006 in “American Journal of Pathology”

SGK3 is essential for proper hair growth and health.

research Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway

28 citations , May 2019 in “Life Sciences”

Ginsenoside Rb1 from Panax ginseng helps mink hair grow by activating certain cell signals.

Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

research Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

4 citations , June 2021 in “Journal of Microbiology and Biotechnology”

Ginsenoside Rg4 from ginseng may help hair growth by activating certain cell signals.

research Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique

1 citations , January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

research Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia

February 2023 in “PLOS ONE”

Caizhixuan hair tonic helps treat hair loss by promoting hair growth and improving hair follicles.

research Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “Molecules”

Adenosine can help treat hair loss by promoting hair growth.

research Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells

22 citations , February 2017 in “Clinical and Experimental Dermatology”

Icariin helps mouse hair grow by boosting a growth factor in skin cells.

research Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

research Enhancement of Hair Growth through Stimulation of Dermal Papilla Cells in Human Follicular Dermal

January 2018 in “Open access journal of pharmaceutical research”

Biofield Energy Healing may increase hair growth by enhancing cell proliferation.

Optimizing Clinical Monitoring and Management Guidelines for Capivasertib in HR-Positive/HER2-Negative Advanced Breast Cancer: Expert Opinion

research Optimizing clinical monitoring and management guidelines for capivasertib in HR-positive/HER2-negative advanced breast cancer: expert opinion

December 2025 in “npj Breast Cancer”

Capivasertib improves survival in certain breast cancer cases but requires careful management of side effects.

Ideal JAK Inhibitor for Alopecia Areata: Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib - Revisiting the Immunomechanisms of the JAK Pathway

research Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway

January 2023 in “Indian Dermatology Online Journal”

No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.

research The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo

August 2021 in “Research Square (Research Square)”

Borneol Essential Oil could be a natural and safe acne treatment.

research Enzymes

March 2008 in “British Journal of Pharmacology”

Enzymes play crucial roles in metabolism, health, and disease management.

research Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients

24 citations , March 2017 in “Archives of Gynecology and Obstetrics”

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

ATP-Competitive mTOR Kinase Inhibitors Delay Plant Growth by Triggering Early Differentiation of Meristematic Cells Without Developmental Patterning Change

research ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change

161 citations , August 2013 in “Journal of experimental botany”

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

Transplantation of Bone Mesenchymal Stem Cells Effectively Promotes Intestine Regeneration to Eliminate Endotoxemia and Reduce Mortality in the Animal Model of Acute Liver Failure

research Transplantation of bone mesenchymal stem cells effectively promotes intestine regeneration to eliminate endotoxemia and reduce mortality in the animal model of acute liver failure

May 2020 in “Research Square (Research Square)”

Bone marrow stem cells help heal intestines and reduce death in liver failure.