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GlossaryPI3K inhibitor

blocks enzyme activity involved in cell growth and survival

A PI3K inhibitor, also known as a phosphoinositide 3-kinase inhibitor, is a type of drug that blocks the activity of the PI3K enzyme. This enzyme is involved in various cellular functions, including growth, proliferation, and survival. By inhibiting PI3K, these drugs can help treat certain cancers and other diseases where PI3K is abnormally active.

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research The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation

15 citations , March 2015 in “Experimental Dermatology”

Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations , January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

research Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis

8 citations , July 2024 in “Journal of Advanced Research”

CDK inhibitors may help treat ARDS and psoriasis but need more testing for safety and effectiveness.

research Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats

28 citations , May 2018 in “Scientific reports”

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

April 2025 in “Annals of Medicine”

CRH can cause hair loss by promoting cell death in hair growth cells.

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

January 2025

CRH causes hair loss by reducing autophagy and increasing cell death in hair cells.

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

January 2025

CRH causes hair loss by reducing cell survival in hair follicles.

research EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals

53 citations , January 2012 in “Developmental Biology”

EGFR signaling is essential for ear cell regeneration in both birds and mammals.

research NF-κB in biology and targeted therapy: new insights and translational implications

1 citations , March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

research Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique

1 citations , January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

research An overview of animal models induced by glucocorticoids

September 2023 in “Physiology and Pharmacology”

Glucocorticoids can cause various health issues, but some treatments may help reduce these effects.

research The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19

15 citations , July 2022 in “Frontiers in Pharmacology”

Cepharanthine may help treat COVID-19 by targeting similar pathways as other inflammatory diseases.

research Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives

9 citations , August 2024 in “International Journal of Molecular Sciences”

Promising treatments for EBS include anti-inflammatory drugs, antibiotics, creams, mTOR inhibitors, and gene editing, but more trials are needed.

research 691 Topical curcumin promotes induction of the murine hair cycle

3 citations , April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Curcumin applied to the skin can start hair growth in mice.

research New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics

August 2023 in “Frontiers in Oncology”

New drugs and therapies targeting specific pathways show promise in treating advanced prostate cancer.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

23 citations , December 2013 in “Molecular cancer therapeutics”

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

research Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

7 citations , August 2022 in “Experimental dermatology”

Blocking YAP/TAZ could be a new way to treat skin cancer.

research Cutaneous adverse effects of targeted therapies

149 citations , January 2015 in “Journal of the American Academy of Dermatology”

Targeted cancer therapies often cause skin side effects, needing dermatologist care.

research Finasteride as a potential tool to improve Mesenchymal stem cell transplantation for myocardial infarction

4 citations , January 2012 in “Medical Hypotheses”

Finasteride may improve stem cell therapy for heart attacks by increasing cell survival.

Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model

research Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model

February 2022 in “Journal of Biomedical Nanotechnology”

Shikonin, a small molecule, speeds up burn wound healing and hair growth by activating the PI3K/Akt pathway.

research Data Sheet 2_Quercetin promotes production of secondary hair follicle stem cells in cashmere goat: a mechanistic study.zip

October 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Quercetin boosts hair follicle stem cell growth and reduces cell death in cashmere goats.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research 1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function

April 2023 in “Journal of Investigative Dermatology”

Changing YBX1 protein activity affects skin stem cell function and aging.

research Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice

85 citations , May 2009 in “Hippocampus”

Progesterone helps adult male mice grow more neurons and improves memory.

TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

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Related Terms

Research

research The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

research Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis

research Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

research EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals

research NF-κB in biology and targeted therapy: new insights and translational implications

research Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique

research An overview of animal models induced by glucocorticoids

research The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19

research Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives

research 691 Topical curcumin promotes induction of the murine hair cycle

research New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

research Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

research Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

research Cutaneous adverse effects of targeted therapies

research Finasteride as a potential tool to improve Mesenchymal stem cell transplantation for myocardial infarction

research Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model

research Data Sheet 2_Quercetin promotes production of secondary hair follicle stem cells in cashmere goat: a mechanistic study.zip

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

research 1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function

research Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

research The Muscarinic Acetylcholine Receptor in Dermal Papilla Cells Regulates Hair Growth

research Progesterone Promotes the Survival of Newborn Neurons in the Dentate Gyrus of Adult Male Mice

research Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy?

research TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs