Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition
January 2025
in “
Discovery Medicine
”
fruit acids glycolic acid UV-induced skin photoaging oxidative stress collagen recovery epidermal keratinization dermal thickness antioxidant enzyme activities SOD CAT GSH-Px collagen levels inflammatory markers MDA IL-6 IL-1β IFN-γ TNF-α PI3K/Akt signaling pathway NF-κB signaling pathway UV skin aging antioxidants collagen skin inflammation PI3K/Akt pathway NF-κB pathway
TLDR Fruit acids can help prevent skin aging from UV exposure.
The study investigates the protective effects of fruit acids, specifically glycolic acid, on UV-induced skin photoaging in rats. Results show that fruit acid treatment reduces oxidative stress and inflammatory responses, enhances collagen recovery, and improves skin structure by decreasing epidermal keratinization and increasing dermal thickness. The treatment also increases antioxidant enzyme activities (SOD, CAT, GSH-Px) and collagen levels while reducing inflammatory markers (MDA, IL-6, IL-1β, IFN-γ, TNF-α). The underlying mechanism involves the inhibition of the PI3K/Akt and NF-κB signaling pathways, suggesting fruit acids as a potential therapeutic for skin photoaging.
