September 2016 in “Journal of dermatological science” The OVOL1-OVOL2 axis is important for hair follicle differentiation and can help diagnose certain hair-related tumors.
9 citations
,
January 2011 in “American Journal of Dermatopathology” Pilomatrixoma involves abnormal hair keratin production and cell death, causing debris and cysts.
1 citations
,
March 2024 in “Ophthalmic Plastic and Reconstructive Surgery” A pilomatrixoma in the eyebrow can cause hair loss and skin lightening.
May 2025 in “Current Women s Health Reviews” There is no direct link between pilomatrixoma and PCOS.
27 citations
,
December 2005 in “Journal of Cutaneous Pathology” The malignant pilomatricoma showed strong epithelial keratin expression, suggesting it may not calcify.
27 citations
,
May 2004 in “Journal of Investigative Dermatology” 158 citations
,
November 1998 in “Cell” β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.
54 citations
,
January 2016 in “Cell reports” Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
54 citations
,
September 1999 in “PubMed” K15 staining helps distinguish basal cell carcinoma from trichoepithelioma.
47 citations
,
February 2014 in “Journal of Cutaneous Pathology” Matrical tumors share a common growth mechanism involving the Wnt pathway and consistent PHLDA1 expression.
23 citations
,
January 2015 in “Journal of The American Academy of Dermatology” People with myotonic dystrophy type 1 have a higher chance of getting skin tumors, including melanoma.
20 citations
,
November 2004 in “Archives of Pathology & Laboratory Medicine” A rare benign skin growth called melanocytic matricoma was identified in a 69-year-old man.
18 citations
,
February 2001 in “Der Hautarzt” A woman with myotonic dystrophy had multiple skin tumors on her scalp, suggesting a genetic link.
9 citations
,
January 2017 in “Virchows Archiv” LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.
4 citations
,
January 2019 in “Journal of cutaneous pathology” The mTOR pathway may be involved in the development of hair follicle tumors, with higher activity in malignant tumors.
2 citations
,
November 2006 in “Pump Industry Analyst” Pilomatricomas don't follow the usual hair follicle cell differentiation process.
September 2025 in “Journal of Veterinary and Animal Sciences” Nine hair follicle tumors were found in dogs.
26 citations
,
May 2001 in “British Journal of Dermatology” Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.
8 citations
,
September 2023 in “Skin Research and Technology” High-frequency ultrasound improves diagnosis accuracy for most subcutaneous lesions.
October 2023 in “Research Review” Some skin tumors from hair follicles and glands can be linked to genetic syndromes and may be benign or malignant.
May 2020 in “International journal of dermatology and venereology” Hair matrix cysts are rare skin nodules with unique features, often needing surgical removal.
Benign skin tumors need accurate diagnosis to ensure proper treatment.
January 2009 in “Repositório Científico do Instituto Politécnico de Viseu (Instituto Politécnico de Viseu)” The skin lesion was diagnosed as a matrical cyst with unusual features.
March 2022 in “JAAD case reports” A man had a non-cancerous, fast-growing skin lump on his arm that was removed with surgery.
5 citations
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June 2016 in “University of Zagreb University Computing Centre (SRCE)” Most canine follicular tumors in Croatia are benign, but some can be malignant, so testing is important.
January 2026 in “Annals of Pathology and Laboratory Medicine” Accurate diagnosis of rare pilomatrix carcinoma is crucial for effective treatment.
12 citations
,
January 2023 in “Current Oncology” Early detection and complete surgical removal are crucial for better outcomes in treating pilomatrix carcinoma.
June 2025 in “British Journal of Dermatology” Melanocytic matricoma can look like skin cancer but is usually harmless; surgery and follow-up are advised.
4 citations
,
December 2024 in “International Journal of Dermatology” Mohs micrographic surgery is more effective than surgical excision for treating pilomatrix carcinoma, with no recurrences.
6 citations
,
June 2010 in “Dermatologica Sinica” Panfolliculoma is a rare, non-cancerous growth related to hair follicles.