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K15 Promoter-Driven Enforced Expression of NKIRAS Exhibits Tumor Suppressive Activity Against the Development of DMBA/TPA-Induced Skin Tumors

research K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors

4 citations , October 2021 in “Scientific Reports”

NKIRAS2 can suppress certain skin tumors but its effect on cancer varies with context and expression level.

research Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins

13 citations , January 2018 in “Advances in experimental medicine and biology”

research Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.

January 2009 in “Bradford Scholars (University of Bradford)”

BMP signaling helps prevent skin tumors by blocking cancer-promoting pathways.

research Human KAP Genes, Only the Half of it? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes

53 citations , June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

KAP genes show significant genetic variability, but its impact on hair traits is unclear.

Spatial Transcriptomic Analysis of Imiquimod-Treated Mouse Skin Reveals Deregulation of Lipid Raft-Associated Markers Reversible by Caveolin Scaffolding Domain Peptide

research 1619 Spatial transcriptomic analysis of imiquimod-treated mouse skin reveals deregulation of lipid raft-associated markers which could be reversed by re-introduction of caveolin scaffolding domain peptide

April 2023 in “Journal of Investigative Dermatology”

The research found that a protein called caveolin-1 is reduced in psoriasis, but reintroducing it can help alleviate some psoriasis symptoms.

Clinical Snippets: R-Spondin2 Amplifies Wnt Signaling for Hair Growth, Gene Expression Differences in Balding Scalp, IKB Regulates hBD2 in Psoriasis, ß-Defensin Gene Cluster and Hidradenitis Suppurativa, Autoantigen Epitopes in Alopecia Areata

research Clinical Snippets

July 2016 in “Experimental Dermatology”

New treatments for hair growth and psoriasis may be possible, and gene differences could affect baldness and the severity of skin conditions.

Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

research Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

26 citations , July 2016 in “PLOS ONE”

Activating β-catenin in certain skin cells speeds up hair growth in mice.

research Identification and dissection of an enhancer controlling epithelial gene expression in skin

29 citations , February 2001 in “Proceedings of the National Academy of Sciences”

A specific DNA region controls skin cell gene expression by working with certain proteins.

research The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt–Sox9 signaling

22 citations , March 2019 in “The Journal of Cell Biology”

The Wave complex controls skin growth by suppressing certain signals.

research Emergence of hereditary hyperplastic gingivitis in Newfoundland and Labrador, Canada: an exploration into the molecular aetiology at both the gene and genome levels

January 2016 in “Memorial University Research Repository (Memorial University)”

Hereditary hyperplastic gingivitis in silver foxes may be linked to errors in the MAPK signaling pathway, influenced by androgens.

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