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GlossaryPlacebo-Controlled

comparison involves an inactive substance to test treatment efficacy

A placebo-controlled study is a type of clinical trial where one group of participants receives the experimental treatment, while another group receives a placebo—a substance with no therapeutic effect, often a sugar pill. This design helps researchers determine the actual effectiveness of the treatment by comparing outcomes between the treated group and the placebo group, thereby accounting for the placebo effect, where participants may experience perceived or actual improvements in their condition simply because they believe they are receiving treatment.

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research A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

research A placebo-controlled, double-blind crossover study of fluoxetine in trichotillomania

180 citations , November 1991 in “American Journal of Psychiatry”

Fluoxetine was not effective in treating hair-pulling disorder in the short term.

research Placebo-controlled oral pulse prednisolone therapy in alopecia areata

141 citations , February 2005 in “Journal of the American Academy of Dermatology”

Oral prednisolone helps hair regrowth in alopecia areata.

Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

research Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: A randomized, double-blind, placebo-controlled, phase III study

92 citations , June 2010 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.

research A double-blind, placebo-controlled study of inositol in trichotillomania

18 citations , November 2016 in “International clinical psychopharmacology”

Inositol was not more effective than a placebo in treating trichotillomania.

research The German Double‐Blind Placebo‐Controlled Evaluation of Topical Minoxidil Solution in the Treatment of Early Male Pattern Baldness

17 citations , July 1988 in “International Journal of Dermatology”

The 2% minoxidil solution is safe and effective for early male pattern baldness.

Minoxidil 2% Lotion for Eyebrow Enhancement: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Comparative Study

research Minoxidil 2% lotion for eyebrow enhancement: A randomized, double-blind, placebo-controlled, spilt-face comparative study

13 citations , November 2013 in “The Journal of Dermatology”

Minoxidil 2% lotion is safe and effective for making eyebrows thicker and fuller.

research A randomized, placebo-controlled trial of 1% topical minoxidil solution in the treatment of androgenetic alopecia in Japanese women.

10 citations , May 2007 in “PubMed”

1% topical minoxidil solution significantly improved hair growth in Japanese women with androgenetic alopecia, with no major side effects.

research Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: A randomized, placebo‐controlled trial

7 citations , December 2020 in “Dermatologic Therapy”

Injections with 0.5% minoxidil effectively treat female hair loss, increasing hair density and thickness.

research Safety and efficacy of ALRV5XR in women with androgenetic alopecia or telogen effluvium: A randomised, double-blinded, placebo-controlled clinical trial

6 citations , June 2021 in “EClinicalMedicine”

ALRV5XR significantly improves hair density in women with hair loss and is well-tolerated.

Sesquiterpene-Enriched Extract of Curcuma Aeruginosa Roxb. Retards Axillary Hair Growth: A Randomized, Placebo-Controlled, Double-Blind Study

research Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

5 citations , January 2018 in “Skin Pharmacology and Physiology”

Curcuma aeruginosa extract lotion significantly reduces underarm hair growth.

research Efficacy and safety of Latilactobacillus curvatus LB-P9 on hair health: a randomized, double-blind, placebo-controlled clinical trial

5 citations , November 2024 in “Frontiers in Nutrition”

LB-P9 supplements improve hair health and satisfaction without side effects.

Placebo-Controlled Dose-Effect Studies with Topical Minoxidil 2% or 5% in Male-Patterned Hair Loss Treated with Oral Finasteride Employing an Analytical and Exhaustive Study Protocol

research Placebo‐controlled dose‐effect studies with topical minoxidil 2% or 5% in male‐patterned hair loss treated with oral finasteride employing an analytical and exhaustive study protocol

5 citations , January 2020 in “Skin Research and Technology”

Minoxidil 5% works better than 2% for hair growth in male-patterned hair loss.

Hair Growth Effect of Traditional Chinese Medicine BeauTop on Androgenetic Alopecia Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial

research Hair growth effect of traditional Chinese medicine BeauTop on androgenetic alopecia patients: A randomized double-blind placebo-controlled clinical trial

5 citations , November 2016 in “Experimental and Therapeutic Medicine”

BeauTop improves hair growth in androgenetic alopecia patients.

The Efficacy of Subcutaneous Slow-Release Melatonin Implants in the Prevention of Canine Flank Alopecia Recurrence Is Uncertain: A Double-Blind, Randomized, Placebo-Controlled Study

research The efficacy of subcutaneous slow‐release melatonin implants in the prevention of canine flank alopecia recurrence is uncertain: A double‐blind, randomized, placebo‐controlled study

3 citations , September 2022 in “Veterinary Dermatology”

Melatonin implants did not effectively prevent hair loss in dogs.

research Safety and efficacy of ALRV5XR in men with androgenetic alopecia: A randomised, double-blinded, placebo-controlled clinical trial

3 citations , September 2021 in “EClinicalMedicine”

ALRV5XR effectively increases hair density in men with androgenetic alopecia without adverse effects.

research A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of Latanoprost for Eyelash Growth in Aesthetic Medicine

2 citations , October 2023 in “Cosmetics”

Latanoprost effectively and safely promotes eyelash growth.

research Placebo controlled clinical evaluation of a topical moisturizer formula containing phytol

1 citations , May 2017 in “Journal of The American Academy of Dermatology”

The moisturizer with phytol improved skin texture and reduced fine wrinkles better than the moisturizer without it.

Efficacy, Safety, and Tolerability of Upadacitinib in Adults and Adolescents With Severe Alopecia Areata: Results From the Randomized, Placebo-Controlled, Double-Blind Phase 3 Program (UP-AA)

research Efficacy, Safety, and Tolerability of Upadacitinib in Adults and Adolescents With Severe Alopecia Areata: Results From the Randomized, Placebo-Controlled, Double-Blind Phase 3 Program (UP-AA)

November 2025 in “SKIN The Journal of Cutaneous Medicine”

Upadacitinib effectively treats severe alopecia areata and is safe.

The Effect of Sublingual Minoxidil on Androgenetic Alopecia in Transgender Individuals Receiving Testosterone for Gender-Affirmation: A 24-Week Single-Centre Double-Blinded, Randomized, Placebo-Controlled Clinical Trial

research 61720 The effect of sublingual minoxidil on androgenetic alopecia in transgender individuals receiving testosterone for gender-affirmation: A 24-week single-centre double-blinded, randomized, placebo-controlled clinical trial

September 2025 in “Journal of the American Academy of Dermatology”

Sublingual minoxidil significantly improves hair growth in transgender individuals on testosterone therapy.

Treatment of Androgenetic Alopecia in Transgender People Receiving Testosterone Therapy With Sublingual Minoxidil: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

research Treatment of androgenetic alopecia in transgender people receiving testosterone therapy with sublingual minoxidil: A randomized, double-blind, placebo-controlled clinical trial

May 2026 in “Journal of the American Academy of Dermatology”

Sublingual minoxidil safely increases hair growth in transgender people on testosterone therapy.

research Is Spontaneous Regrowth in Alopecia Areata Possible: A Systematic Review and Meta-analysis of Placebo-controlled Studies

October 2025 in “Acta Dermato Venereologica”

Spontaneous hair regrowth in alopecia areata is possible but varies greatly among individuals.

Safety and Clinical Efficacy of Kūlaris, an Herbal Supplement for Mild to Severe Acne Vulgaris: A 12-Week Randomized, Double-Blind, Placebo-Controlled Study

research Safety and Clinical Efficacy of KūlarisTM, an Herbal Supplement for Mild to Severe Acne Vulgaris – A 12-Week Randomized, Double Blind, Placebo-Controlled Study

September 2025 in “Clinical Cosmetic and Investigational Dermatology”

Kūlaris improved quality of life for acne sufferers without side effects.

LB1139 AMP-303 Injectable Treatment for Androgenetic Alopecia: A Multicenter, Randomized, Placebo-Controlled Feasibility Study of a Novel Polysaccharide

research LB1139 AMP-303 injectable treatment for androgenetic alopecia: A multicenter, randomized, placebo-controlled feasibility study of a novel polysaccharide

July 2025 in “Journal of Investigative Dermatology”

AMP-303 safely increases hair growth in men with hair loss.

Supplementary Material for: Sesquiterpene-Enriched Extract of Curcuma Aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

research Supplementary Material for: Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

January 2018 in “Figshare”

Curcuma aeruginosa extract lotion effectively reduces underarm hair growth.

research Evaluation of Platelet Rich Plasma for Treatment of Female Pattern Hair Loss: A Placebo-Controlled Case Study

December 2022 in “Journal of Dermatology Research”

Platelet Rich Plasma (PRP) treatment significantly improved Female Pattern Hair Loss in a study, but more trials are needed for confirmation.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men

2 citations , April 2024 in “Journal of Clinical Psychopharmacology”

Dutasteride helps reduce heavy drinking, especially for those who drink to cope.

research Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects

March 2024 in “Clinical, cosmetic and investigational dermatology”

Skin Radiance Collagen improved skin and hair health in adult females.

research Multicenter double blind randomized placebo controlled clinical trial of minoxidil gel in the treatment of alopecia areata

January 2006 in “The Chinese Journal of Clinical Pharmacology”

2.2% minoxidil gel effectively and safely treats alopecia areata.