45 citations
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January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.
28 citations
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August 2003 in “Steroids” Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.
3 citations
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January 2017 in “Gynecological endocrinology” A postmenopausal woman's excess male hormone symptoms were caused by a rare adrenal gland tissue in her ovary.
8 citations
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March 2010 in “Gynecological Endocrinology” Free Testosterone Index, bioavailable testosterone, and androstenedione are the most accurate for diagnosing excess male hormones in PCOS.
17 citations
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October 2005 in “Journal of Biological Chemistry” Early involution in Hirosaki hairless rats' mammary glands is linked to a unique modification of STAT5A.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” Steroid-producing capabilities in certain cancers may contribute to treatment resistance.
August 2025 in “DS Reviews of Research in Life Sciences” Women with PCOS have higher levels of DHEA, IL-6, and TNF-α.
17 citations
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December 2004 in “Bioorganic & Medicinal Chemistry Letters” Scientists found new, better-working inhibitors for a hormone-related enzyme.
2 citations
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July 2024 in “Cureus” Injecting endometrial cells and PRP can improve pregnancy chances in ART.
10 citations
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September 2015 in “Folia Histochemica Et Cytobiologica” Finasteride treatment in male rats can reduce fertility and affect sperm development in their offspring.
46 citations
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August 2006 in “PubMed” A genetic defect causes males in some Mediterranean populations to be born with ambiguous genitalia and develop male traits at puberty.
January 2002 in “HAL (Le Centre pour la Communication Scientifique Directe)” The enzyme system in hair follicles is similar to the liver's and is inhibited by certain substances.
18 citations
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December 2005 in “Journal of Medicinal Chemistry” A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.
26 citations
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June 2003 in “PubMed” Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.
4 citations
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May 2024 in “Steroids” The method accurately measures sex hormones in human plasma but can have small errors.
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January 2001 in “PubMed” 24 citations
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March 1996 in “Postgraduate Medical Journal” Most women with hirsutism in the UAE have polycystic ovary syndrome (PCOS).
98 citations
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July 1983 in “Journal of Steroid Biochemistry” Individuals with this condition often develop male traits and identities at puberty despite being raised as females.
202 citations
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January 1989 in “Journal of Clinical Investigation” Insulin changes sex hormone levels in women with polycystic ovary syndrome without affecting other hormone releases.
12 citations
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March 2013 in “Gynecological Endocrinology” The study found a significant link between the renin-angiotensin system and insulin resistance in women with polycystic ovary syndrome.
18 citations
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February 2012 in “Experimental Dermatology” No link found between specific genes and female pattern hair loss.
6 citations
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October 2018 in “Endocrinology” Prenatally androgenized ewes can model increased hair diameter in women with PCOS.
April 2019 in “Journal of the Endocrine Society” A woman's severe insulin resistance improved with treatment, but she still had high testosterone levels due to ovarian issues.
January 1983 in “Elsevier eBooks” Masculinization in affected individuals occurs gradually after puberty due to hormone changes.
June 2003 in “Obstetrical & Gynecological Survey” After chemotherapy for a gestational trophoblastic tumor, normal pregnancy rates are possible, but there's a slightly higher risk of the tumor reoccurring in future pregnancies.
2 citations
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April 2020 in “Clinical and experimental obstetrics & gynecology” Hair levels of estradiol and progesterone are higher in premenopausal than postmenopausal women, but the difference isn't statistically significant, indicating the need for a better measurement method.
1 citations
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July 2016 in “Elsevier eBooks” Understanding skin structure and development helps diagnose and treat skin disorders.
Tiny particles called extracellular vesicles show potential for improving skin health in cosmetics, but more research is needed to confirm their safety and effectiveness.
September 2009 in “European journal of paediatric neurology” Biotin supplements did not significantly reduce hair loss in rats on valproic acid.
November 2003 in “Aap Grand Rounds” Low-dose flutamide-metformin therapy effectively improved PCOS symptoms in adolescent girls.