260 citations
,
July 2010 in “Cell” Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.
159 citations
,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
98 citations
,
July 2014 in “Trends in Molecular Medicine” Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.
68 citations
,
April 2014 in “Journal of Molecular Endocrinology” The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.
25 citations
,
June 2019 in “Endocrine Related Cancer” Mutations in certain receptors can cause diseases and offer new treatment options.
25 citations
,
May 2003 in “Expert Opinion on Therapeutic Patents” Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.
24 citations
,
July 2018 in “Stem cells” Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.
22 citations
,
January 2008 in “Physiological Research” Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.
17 citations
,
August 2018 in “BMC Genomics” The HOXC13 gene affects different hair proteins in cashmere goats in varied ways and is controlled by a feedback loop and other factors.
11 citations
,
April 2013 in “Journal of Proteomics” Found different proteins in balding and non-balding cells, giving insight into hair loss causes.
9 citations
,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
7 citations
,
June 2017 in “Omics” The study developed a method to analyze ancient hair proteins using very small samples.
4 citations
,
January 2020 in “Cells” The research found that the gene activity in mouse skin stem cells changes significantly as they age.
2 citations
,
November 2019 in “Cancer reports” The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.
1 citations
,
November 2025 in “Frontiers in Immunology” More research is needed to understand and manage rheumatoid arthritis better.
1 citations
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December 2018 in “IntechOpen eBooks” Human hair shows promise for non-invasive medical testing, but more research is needed to standardize its use.
July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” Examining Survivin levels may help understand premature greying of hair.
January 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Mothers have more hair proteins than their children, with age-related differences in protein patterns, and some proteins in hair could indicate early childhood development.
Plant roots respond to fungus smells by possibly using certain proteins and a plant hormone to change root growth, but more research is needed.
December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.
The research found that people's hair proteins vary, especially by ethnicity and body part, which could help identify individuals in forensic science.
The research found that people's hair proteins vary by individual and body part, with some differences between ethnic groups, which could help in forensics.
January 2001 in “Cambridge University Press eBooks” Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.
556 citations
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September 2008 in “Genes & Development” Wnt signaling is vital for cell growth, development, and cancer research.
438 citations
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October 2010 in “Oncogene” Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.
341 citations
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November 2009 in “The FASEB Journal” Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.
232 citations
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January 2013 in “Nature Cell Biology” Understanding where cancer cells come from helps create better prevention and treatment methods.
222 citations
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October 2014 in “Annual Review of Pharmacology and Toxicology” Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.
195 citations
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April 2005 in “Journal of biological chemistry/The Journal of biological chemistry” The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.
169 citations
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June 2010 in “Molecular & cellular proteomics” Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.