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research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

271 citations , May 2019 in “Cells”

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

research The diagnosis and treatment of iron deficiency and its potential relationship to hair loss

207 citations , April 2006 in “Journal of The American Academy of Dermatology”

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

research Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential

187 citations , April 2019 in “npj Regenerative Medicine”

Wharton's jelly secretomes are best for promoting blood vessel growth.

research Basal cell carcinoma — molecular biology and potential new therapies

146 citations , February 2012 in “Journal of Clinical Investigation”

Blocking Hedgehog signaling offers new treatment options for advanced basal cell carcinoma.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

142 citations , March 2019 in “Molecules/Molecules online/Molecules annual”

Cannabinoids may help treat various skin conditions.

research Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.)

142 citations , November 2009 in “BMC Complementary and Alternative Medicine”

Tridax procumbens significantly lowers blood sugar in diabetic rats.

research Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium

138 citations , June 2019 in “Stem Cells and Development”

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity

research A preliminary observation: Male pattern hair loss among hospitalized COVID‐19 patients in Spain – A potential clue to the role of androgens in COVID‐19 severity

134 citations , April 2020 in “Journal of Cosmetic Dermatology”

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing

128 citations , August 2020 in “Cell stem cell”

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

research Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

97 citations , December 2010 in “Journal of Neuroscience”

Midazolam impairs learning and memory by increasing neurosteroids through specific receptor activation.

research PCOS and Depression: Common Links and Potential Targets

96 citations , October 2021 in “Reproductive Sciences”

Women with PCOS often experience depression and anxiety, affecting their quality of life.

research Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial

81 citations , July 2012 in “Translational Psychiatry”

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature

research Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature

80 citations , June 2020 in “Dermatopathology”

COVID-19 can cause various skin lesions, which may result from the virus and immune response, and are not directly linked to illness severity.

research Analysis of the sheep trichohyalin gene: potential structural and calcium-binding roles of trichohyalin in the hair follicle.

72 citations , May 1993 in “The Journal of Cell Biology”

Trichohyalin in sheep hair follicles may help with structure and calcium binding.

research Epidermal stem cells: practical perspectives and potential uses

62 citations , April 2009 in “British Journal of Dermatology”

Epidermal stem cells could lead to new treatments for skin and hair disorders.

research Platelet-rich plasma as a potential treatment for noncicatricial alopecias

58 citations , January 2015 in “International Journal of Trichology”

Platelet-rich plasma, which carries growth factors, could be a promising treatment for non-scarring hair loss, promoting hair growth and density with no major side effects.

research Macrophages in Skin Wounds: Functions and Therapeutic Potential

56 citations , November 2022 in “Biomolecules”

Targeting macrophages may improve wound healing.

research Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors

56 citations , February 2013 in “International Journal of Molecular Medicine”

Growth factors help hair follicle stem cells grow and stay versatile.

research Transcriptome Profile at Different Physiological Stages Reveals Potential Mode for Curly Fleece in Chinese Tan Sheep

55 citations , August 2013 in “PloS one”

Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.

research Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways

54 citations , June 2023 in “International Journal of Molecular Sciences”

Myricetin shows promise as an anticancer agent by reducing inflammation and enhancing drug effectiveness.

research Edible seeds from Cucurbitaceae family as potential functional foods: Immense promises, few concerns

54 citations , May 2017 in “Biomedicine & Pharmacotherapy”

Edible seeds from the Cucurbitaceae family like pumpkin and watermelon seeds are nutritious and may have health benefits, but eating too much can cause side effects.

research Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes

44 citations , February 2009 in “Pain”

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

research Combined transcriptomics and proteomics forecast analysis for potential genes regulating the Columbian plumage color in chickens

43 citations , November 2019 in “PLoS ONE”

This study investigated the molecular mechanisms behind the Columbian plumage color in the "Yufen I" H line of chickens by analyzing transcriptomic and proteomic differences in feather follicles. Researchers identified 21,306 genes and 5,203 proteins, with 209 genes and 382 proteins differentially expressed between black and white striped feathers and white feathers. Key findings included the involvement of 8 differentially expressed genes (DEGs) and 9 differentially expressed proteins (DEPs) in the melanogenesis pathway, with MED23 and GNAQ playing crucial roles in melanin synthesis. The study highlighted the activation of pathways such as melanogenesis and cardiomyocyte adrenergic, and validated gene expression through qRT-PCR. The research provided insights into gene and protein variations during feather color development, offering a foundation for future breeding and functional genomics studies.

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