research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-methylpregna-4,6-diene-3,20-dione
A new compound that could treat various androgen-related conditions was created and analyzed.
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research Crystal Structure and Synthesis of 3.BETA.-Benzoyloxy-4-pregnen-16.ALPHA.,17.ALPHA.-epoxy-6,20-dione
The document explains how to make a compound called 3.BETA.-Benzoyloxy-4-pregnen-16.ALPHA.,17.ALPHA.-epoxy-6,20-dione and describes its crystal structure.
research Molecular Interactions of New Pregnenedione Derivatives
The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
research Synthesis of a 4-azasteroid hormones compound
Finasteride was successfully synthesized from Pregnadienolone acetate.
research Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease
Pregnenolone might help manage movement issues caused by Parkinson's disease treatment without reducing the medicine's effectiveness.
research 3a-Phenylhexahydropentalene-1,6-dione
A rigid compound with a common structural motif was successfully synthesized.
research Dienogest
Dienogest combined with ethinylestradiol is a highly effective birth control that improves menstrual symptoms and has manageable side effects.
research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.
Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
research Biology and Detection of Pregnanes During Late Gestation in the Mare
LC-MS/MS is essential for accurately detecting pregnanes in pregnant mares.
research The neurosteroid metabolite of progesterone, 3α‐OH‐dihydroprogesterone (3α‐OH‐DHP), is required for attenuated baroreflex mediated sympathoexcitation in pregnancy
3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.
research New Synthesis of Methyl 3β-Hydroxy-5-androstene-17β-carboxylate
A new method was developed to make a compound used in finasteride and epristeride with a 69% yield.
research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.
New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.
research PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields
Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.
research New Synthesis of Finasteride
A new method to make Finasteride is more cost-effective and yields 16%.
research Synthesis of 11α-hydroxyprogesterone hartens
Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.
research The effects of synthetic 19-norprogestins on osteoblastic cell function are mediated by their non-phenolic reduced metabolites
Synthetic 19-norprogestins promote bone cell growth and function through their non-phenolic metabolites.
research A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives
A new, efficient method was developed to synthesize a specific compound and its derivatives.
research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors
Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.
research Progestogens with Antiandrogenic Properties
research A clinico-pathological study of Neogynon as a new oral contraceptive steroid.
Neogynon effectively prevents pregnancy but may cause side effects like headaches and menstrual changes.
research A new method for synthesis of finasteride
A new, safer method to make finasteride from progesterone is effective for industrial use.
research New Aromatic Esters of Progesterone as Antiandrogens
New progesterone-based compounds can block male hormones.
research Synthesis of finasteride
The process to make finasteride is simple, cheap, and gives a good amount.
research Estrogens
research Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors
Certain progesterone derivatives can inhibit enzymes and reduce androgenic activity, potentially affecting prostate growth.
research Neuroactive Steroids: Functions, Mechanisms of Action and Physiologic Relevance
Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.
research The anticonvulsant effects of progesterone and its metabolites
5alpha-DHP may be a safe, effective treatment for certain seizures without causing sedation.
research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1
A new compound effectively inhibits human 5α-reductase 1.
research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond
The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.
research Core-shell nanocarriers based on PEGylated hydrophobic hyperbranched polyesters
The new nanocarriers improve how well water-insoluble drugs dissolve and allow for controlled drug release.