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Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

A woman's increased hair growth during pregnancy due to PCOS resolved after delivery.

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.

Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Stopping alcohol after long-term use causes anxiety and changes brain chemicals.

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Norethisterone (jenapharm) therapy is effective for endometrial cancer.

Progesterone protects brain cells by converting to allopregnanolone and involving GABAA receptors.

A new method accurately measures nine neuroactive steroids in small blood samples, helping to study brain diseases.

Finasteride was successfully synthesized from Pregnadienolone acetate.

Analog 23 is a promising compound for prostate cancer treatment.

Finasteride may affect PNMT, causing side effects.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

TCDD reduces EGF receptors in the liver, affecting growth and development.

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

Blocking neurosteroid production can lead to more seizures and faster epilepsy onset in rats.

New steroid derivatives show promise as anticancer agents, even against resistant cells.

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

Different rat and mouse strains respond differently to stress and alcohol, which may help us understand similar human mechanisms.

5alpha-DHP may be a safe, effective treatment for certain seizures without causing sedation.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

Prenatal pesticide exposure may cause earlier breast development in girls.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

Chromosomal differences affect how muscle cells respond to testosterone.

Certain peptides can prevent hair loss in young rats caused by a cancer drug.

Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.

Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.