research Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin
Calcifying epithelioma cells can differentiate into hair cortex and outer root sheath.
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research Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin‐based cornification during hair evolution
Monotreme hair structure and protein distribution are similar to other mammals, but their inner root sheath cornifies differently, suggesting a unique evolution from reptile skin.
research Desmosomes in Developing Human Epidermis
Desmosomes are crucial for human skin development, increasing in density as the skin matures.
research Mechanical anisotropy of hair affected by genetic diseases highlights structural information related to differential crosslinking in keratins
research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia
research Apoptosis in human skin development: Morphogenesis, periderm, and stem cells
Apoptosis is essential for human skin development and forming a functional epidermis.
research Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice
Mice with human skin protein K8 had more skin problems and cancer.
research Organization of microfibrils in keratin fibers studied by X-ray scattering
The study improved understanding of keratin fiber structure by showing consistent microfibril diameter but varying distances and electron density profiles.
research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability
Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.
research Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development
Dermal EZH2 controls skin cell development and hair growth in mice.
research Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Too much parathyroid hormone-related protein in skin disrupts hair growth in mice.
research Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis
ABCG2 protein marks stem-like skin cells in human epidermis.
research Staining of human skin with RGB trichrome unveils a proteoglycan-enriched zone in the hair dermal sheath
A new staining method shows a special area in the hair's skin layer with lots of proteoglycans.
research Strategies for improved hair binding: Keratin fractions and the impact of cationic substructures
Certain treatments can increase protein binding to natural hair but are less effective on permed hair.
research Hair growth promoting activity of discarded biocomposite keratin extract
Keratin extract from human hair was found to promote hair growth in mice.
research A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.
A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.
research An epidermis‐permeable dipeptide is a potential cosmetic ingredient with partial agonist/antagonist activity toward fibroblast growth factor receptors
Pro-Ile could be used in cosmetics to improve skin, hair growth, and healing.
research Soluble and insoluble collagen and elastin in the rat hair cycle
research Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay
Certain genetic variants in keratins increase the risk of tooth decay.
research Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers
Scientists created 3D hair-like structures that could help study hair growth and test treatments.
research Epidermal Barrier
Healthy skin prevents water loss and protects against threats.
research Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex
Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.
research Identification of hair shaft progenitors that create a niche for hair pigmentation
Scientists found cells in hair that are key for growth and color.
research 0749 Serine and arginine-rich splicing factor 3 regulates epidermal differentiation in cutaneous squamous cell carcinoma
research Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages
Touch dome keratinocytes in adult skin have traits of different skin cell types.
research Harlequin fetus with abnormal lamellar granules and giant mitochondria
Harlequin ichthyosis involves abnormal skin cell structures and giant mitochondria, affecting skin and hair.
research Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis
Deleting a specific protein in skin cells disrupts normal hair growth and development.
research Special issue on epidermal and hair follicle differentiation, part 2
research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome
The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.