51 citations
,
May 2021 in “Nature Communications” High proliferation and cell delamination drive early skin development, while later stages may not rely on cell division orientation.
43 citations
,
February 2013 in “Developmental dynamics” Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.
43 citations
,
August 2008 in “Regenerative Medicine” Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.
37 citations
,
May 2018 in “Frontiers in physiology” Certain RNA molecules are important for the development of wool follicles in sheep.
27 citations
,
August 2014 in “Wiley interdisciplinary reviews. Developmental biology” The skin and thymus develop similarly to protect and support immunity.
20 citations
,
September 2021 in “Nature communications” Cat color patterns are determined early in development by gene expression and epidermal changes, with the Dickkopf 4 gene playing a crucial role.
18 citations
,
March 2023 in “Molecular Therapy — Nucleic Acids” Mechanical stimuli and CCL2 can help regenerate hair follicles in adult mice.
17 citations
,
December 2006 in “Gene Expression Patterns” Scube3 gene affects mouse embryo growth in multiple areas, but needs more research.
17 citations
,
January 1997 in “Cell and Tissue Research” Scientists developed a method to grow human fetal skin and digits in a lab for 3-4 weeks, which could help study skin features and understand genetic interactions in tissue formation.
12 citations
,
August 2016 in “Current opinion in genetics & development” Organs like hair follicles can renew themselves in complex ways, adapting to different needs and environments.
5 citations
,
December 2021 in “Journal of Investigative Dermatology” Hedgehog signaling in certain cells is crucial for hair growth during wound healing.
2 citations
,
February 2025 in “PLoS ONE” Key proteins influence wool quality by affecting hair follicle development in sheep.
2 citations
,
July 2023 in “Animals” FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.
2 citations
,
December 2011 in “Annales de Dermatologie et de Vénéréologie” 2011 dermatological research found new skin aging markers, hair loss causes, skin defense mechanisms, and potential for new treatments.
1 citations
,
February 2023 in “ACS Biomaterials Science & Engineering” The new microwell device helps grow more hair stem cells that can regenerate hair.
1 citations
,
July 2016 in “Elsevier eBooks” Understanding skin structure and development helps diagnose and treat skin disorders.
1 citations
,
October 2013 Different ectodermal organs like hair and feathers regenerate differently, with specific stem cells and signals involved in their growth and response to the environment.
December 2025 in “The Journal of Basic and Applied Zoology” Red Sokoto goat fetuses develop firmer, pigmented skin with hair follicles as they grow.
January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” The gene Ascl4 is not necessary for the development of hair, teeth, or mammary glands.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.
April 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Sweat gland development involves two unique skin cell programs and a temporary skin environment.
January 2022 in “Springer eBooks” Fibroblast growth factors are crucial for hair follicle development and regeneration.
March 2021 in “Research Society and Development” A blue Staffordshire Bull Terrier had hair loss due to color dilution alopecia, confirmed by tests, but no treatment was pursued.
June 2006 in “Experimental Dermatology” Understanding skin patterns can help us learn about skin diseases and their treatments.
11 citations
,
June 2017 in “Asian-Australasian journal of animal sciences” Fox genes are important for hair growth and development in cashmere goats.
112 citations
,
January 2014 in “Molecular and cellular therapies” Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
87 citations
,
February 2000 in “Journal of Investigative Dermatology” Stem cells in developing hair follicles move to specific areas as they mature.
86 citations
,
October 2005 in “Experimental Dermatology” The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
69 citations
,
August 1999 in “Developmental biology” The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
25 citations
,
May 2013 in “Journal of mammary gland biology and neoplasia” Hedgehog signaling is crucial for mammary gland development over hair follicles.