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research 5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives

26 citations , October 2011 in “International Journal of Biological Macromolecules”

Some newly made compounds are promising for treating enlarged prostate, hair loss, viruses, and prostate cancer, and might be better than current drugs.

research Polymeric nanoparticles-embedded organogel for roxithromycin delivery to hair follicles

47 citations , July 2014 in “European Journal of Pharmaceutics and Biopharmaceutics”

Scientists created a gel with nanoparticles to deliver medicine to hair follicles effectively.

research Balancing metabolic optimization and reproductive safety in Polycystic Ovary Syndrome: a Bayesian-informed framework for GLP-1 receptor agonists

June 2026 in “Frontiers in Nutrition”

The document discusses the use of GLP-1 receptor agonists (GLP-1RAs) in managing Polycystic Ovary Syndrome (PCOS), focusing on their metabolic benefits rather than confirmed fertility enhancement. The narrative synthesis highlights the need for individualized treatment plans, emphasizing the distinction between metabolic optimization and reproductive outcomes. The study suggests GLP-1RAs should be used as short-term, preconception tools, with careful planning for drug discontinuation to avoid rebound effects. The authors call for future trials to standardize reproductive endpoints and capture periconception exposure to better assess the benefits and risks.

research Relative binding affinity of novel steroids to androgen receptors in hamster prostate

5 citations , January 2005 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

New steroids were effective in blocking male hormone receptors in hamster prostates.

research Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor

17 citations , October 2006 in “Molecular and Cellular Endocrinology”

The L457(3.43)R mutation in the human lutropin receptor causes increased activity and hormone insensitivity, leading to precocious puberty.

research Pharmacophore and Atom Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors

2 citations , November 2018 in “Indian Journal of Pharmaceutical Education”

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers?

research Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?

6 citations , April 2014 in “European journal of medicinal chemistry”

New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.

Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid

research Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

2 citations , November 2017 in “PloS one”

Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

research Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer

February 2024 in “Cancers”

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

research RU 58841-myristate–prodrug development for topical treatment of acne and androgenetic alopecia.

26 citations , January 2005 in “PubMed”

RUM-loaded SLN shows promise for treating acne and hair loss topically.

research Development of radioiodinated nonsteroidal androgen receptor ligands for spect imaging of prostate cancer

1 citations , May 2001 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.

research Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice

4 citations , January 2025 in “International Journal of Molecular Sciences”

Progesterone reduces anxiety and depression in female mice by increasing BDNF in the brain, needing 5α-reduction and estradiol.

research Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

14 citations , May 2021 in “Marine Drugs”

PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.

Sigma-1 Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward

research ς₁Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward

100 citations , May 2003 in “Journal of Neuroscience”

Neuroactive steroids affect cocaine's rewarding effects through the ς₁ receptor.

research Synthesis of 17β-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line

11 citations , June 2016 in “European Journal of Medicinal Chemistry”

Compounds 6f and 6g effectively stop prostate cancer cell growth without harming healthy cells.

research Advancements in Drug Repurposing: Examples in Psychiatric Medications

1 citations , July 2023 in “International Journal of Molecular Sciences”

Old psychiatric drugs are increasingly being used for new purposes, and technologies like SmartCube® help create new drugs.

research FPRL1 Receptor Agonist Peptides Prevent Etoposide-Induced Alopecia in Neonatal Rats

8 citations , June 2004 in “Journal of Investigative Dermatology”

Certain peptides can prevent hair loss in young rats caused by a cancer drug.

research Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens

14 citations , November 2014 in “European journal of medicinal chemistry”

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

research Liarozole—a novel treatment approach for advanced prostate cancer: results of a large randomized trial versus cyproterone acetate

52 citations , July 1998 in “Urology”

Liarozole may be more effective than cyproterone acetate for treating advanced prostate cancer, with better PSA response and survival rates, while maintaining quality of life.

Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model

research Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model

15 citations , January 2024 in “The AAPS Journal”

50-mg ritlecitinib capsules are bioequivalent to 100-mg capsules.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice

29 citations , October 2009 in “Pharmacology Biochemistry and Behavior”

research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate

3 citations , January 2003 in “Synthetic Communications”

Scientists made two new chemicals that might help treat diseases caused by male hormones.

research 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration

April 2019 in “Journal of Investigative Dermatology”

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

research Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor

18 citations , October 2010 in “Bioorganic & Medicinal Chemistry Letters”

New hybrid compound found to effectively prevent hair loss.

Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals

research Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals

25 citations , November 2013 in “PLoS ONE”

Estrogen and androgen signals control synaptic changes in rat brains.

Core-Shell Nanocarriers Based on PEGylated Hydrophobic Hyperbranched Polyesters

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